Scelta multipla
True or False? The process of affinity maturation generates antibodies with an increasing capacity to bind antigens and thus to more efficiently bind to, neutralize, and eliminate microbes.
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20. Adaptive Immunity
Affinity Maturation
Scelta multipla
How does an antibody's ability to bind an antigen increase as B cells multiply?
A
Genetic rearrangement of the DNA encoding the antibody's constant region occurs with each B cell generation.
B
Genetic mutations of the DNA encoding the antibody's variable region occur with each B cell generation.
C
Variation in the amino acid sequence of the antibody stem occurs & allows the antibody to bind various antigens.
D
Genetic mutations of the DNA encoding the antibody occur changing the antibody into a BCR.
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Understand the role of B cells in the immune response: B cells are a type of white blood cell that produce antibodies to bind specific antigens, which are foreign substances that elicit an immune response.
Recognize the importance of the antibody's variable region: The variable region of an antibody is responsible for binding to a specific antigen. This region is highly specific and can vary greatly between different antibodies.
Learn about somatic hypermutation: As B cells multiply, they undergo a process called somatic hypermutation, where genetic mutations occur in the DNA encoding the antibody's variable region. This increases the diversity of antibodies and enhances their ability to bind to antigens more effectively.
Understand affinity maturation: Through somatic hypermutation, B cells that produce antibodies with higher affinity for the antigen are selected for survival and proliferation. This process is known as affinity maturation and results in a more effective immune response.
Differentiate between the variable and constant regions: The constant region of an antibody does not change during somatic hypermutation. It is the variable region that undergoes genetic mutations, allowing for increased binding affinity to antigens.
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