Which explanation best accounts for why quinolones produce lethal damage predominantly during DNA replication?

Design a brief experimental approach to demonstrate that a new antibacterial compound causes double-strand DNA breaks in bacteria rather than merely inhibiting replication. Which combined methods would give the most direct evidence?

Which antibiotic directly targets mycolic acid synthesis and is therefore specific for mycobacteria?

Which statement best distinguishes polypeptide antibiotics from beta-lactam antibiotics in structure and primary mechanism of action?

Devise a rationale explaining why isoniazid resistance often results from mutations in katG (encoding a bacterial catalase-peroxidase) and how that affects therapy design.