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Type II Hypersensitivities definitions
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Type II Hypersensitivity
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Type II Hypersensitivity
Immune reaction where IgG or IgM antibodies target cell surface antigens, often resulting in cell destruction or altered cell function.
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Termini in questo insieme (15)
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Type II Hypersensitivity
Immune reaction where IgG or IgM antibodies target cell surface antigens, often resulting in cell destruction or altered cell function.
Cytotoxic Hypersensitivity
Immune response causing cell death through antibody binding, leading to lysis or tissue damage, often via complement activation.
IgG
Antibody class involved in targeting antigens on cell surfaces, capable of crossing the placenta and mediating cytotoxic effects.
IgM
Large antibody class that initiates immune responses against cell-bound antigens, especially in early stages of Type II reactions.
Antigen
Molecule on cell surfaces recognized by antibodies, determining blood type compatibility and triggering immune responses.
ABO Blood System
Classification based on presence or absence of A and B carbohydrate antigens on red blood cells, crucial for transfusion safety.
Rh Factor
Protein antigen on red blood cells that determines positive or negative blood type status and influences transfusion compatibility.
Hemolytic Transfusion Reaction
Destructive immune response where recipient antibodies attack incompatible donor red blood cells, causing lysis and organ damage.
Hemolytic Disease of the Newborn
Condition where maternal antibodies destroy fetal red blood cells, leading to anemia and severe complications in Rh-positive fetuses.
Antibody-Dependent Cellular Cytotoxicity
Mechanism where antibodies tag cells for destruction by immune cells, resulting in targeted cell death.
Complement System
Cascade of plasma proteins activated by antibodies, leading to cell lysis and amplification of immune responses.
RhoGAM
Medication containing anti-Rh antibodies, administered to prevent maternal sensitization and protect future Rh-positive pregnancies.
Autoimmune Hemolytic Anemia
Disorder where antibodies target and destroy one's own red blood cells, resulting in anemia.
Isohemagglutinin
Naturally occurring antibody against ABO blood group antigens not present on an individual's own red blood cells.
Universal Donor
Blood type lacking A, B, and Rh antigens, allowing safe donation to all recipients regardless of their blood type.