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Microbiology: Pathology, Infection, and Disease

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  • What is pathology?

    Pathology is the study of disease.

  • Define etiology.

    Etiology refers to the cause of a disease.

  • What does pathogenesis describe?

    Pathogenesis describes how a disease develops.

  • What is infection?

    Infection is the invasion or colonization of the body by pathogens.

  • When does an infectious disease occur?

    An infectious disease occurs when an infection changes the state of health.

  • What is the human microbiome?

    The human microbiome begins developing at birth and consists of normal and transient microbiota.

  • Difference between normal and transient microbiota

    Normal microbiota permanently colonize the body; transient microbiota remain for days, weeks, or months.

  • What is microbial antagonism?

    Microbial antagonism, or competitive exclusion, is when normal microbiota compete with pathogens for nutrients and space.

  • How can normal microbiota harm invading microorganisms?

    Normal microbiota may produce substances harmful to invading microorganisms.

  • What is fecal microbial transfer used for?

    Fecal microbial transfer may help restore normal microbiota, especially after Clostridium difficile infections.

  • Define commensalism.

    Commensalism benefits one organism while the other is unaffected.

  • Define mutualism.

    Mutualism benefits both organisms involved.

  • Define parasitism.

    Parasitism benefits one organism at the expense of the host.

  • Difference between symptoms and signs

    Symptoms are subjective changes felt by the patient; signs are objective changes observed or measured.

  • What is a syndrome?

    A syndrome is a group of signs and symptoms occurring together.

  • What is a communicable disease?

    Communicable diseases spread from one person to another.

  • Example of a non-communicable disease

    Tetanus is an example of a non-communicable disease.

  • Define incidence in disease occurrence

    Incidence is the number of new cases during a specific time period.

  • Define prevalence in disease occurrence

    Prevalence includes both old and new cases of a disease in a population.

  • What is an endemic disease?

    An endemic disease is constantly present in a population.

  • What is a pandemic?

    A pandemic is a worldwide epidemic.

  • Difference between acute and chronic diseases

    Acute diseases develop rapidly and last a short time; chronic diseases develop slowly and last longer.

  • What is a latent disease?

    A latent disease becomes inactive and later reactivates.

  • Define herd immunity

    Herd immunity occurs when most of a population is immune to a disease.

  • Difference between local and systemic infection

    A local infection is limited to a small area; a systemic infection spreads through blood and lymph.

  • What is septicemia?

    Septicemia involves bacterial growth in the blood.

  • What is a primary infection?

    A primary infection causes the initial disease.

  • What is a secondary infection?

    A secondary infection follows a primary infection.

  • What are predisposing factors?

    Predisposing factors increase susceptibility to disease, such as age, nutrition, vaccination status, and stress.

  • Stages of disease development

    Stages include incubation period, prodromal period, period of illness, and convalescence.

  • What are reservoirs of infection?

    Reservoirs are continual sources of infections, including asymptomatic carriers, animals (zoonoses), soil, and water.

  • Define direct contact transmission

    Direct contact transmission requires close physical contact between hosts.

  • What is a fomite?

    A fomite is a nonliving object that can transmit pathogens indirectly.

  • Difference between mechanical and biological vector transmission

    Mechanical transmission carries pathogens on the vector's body surface; biological transmission involves pathogen reproduction inside the vector.

  • What are healthcare-associated infections (HAIs)?

    HAIs are infections acquired while receiving treatment in a healthcare facility.