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Ch. 20 - Urinary and Reproductive System Infections
Norman-McKay- Microbiology: Basic and Clinical Principles 2nd Edition
Norman-McKay2nd EditionMicrobiology: Basic and Clinical PrinciplesISBN: 9780137661619Non è quello che usi tu?Cambia libro di testo
Capitolo 16, Problema 10

Patients can contract chlamydia more than once because:
a. It is so commonly antibiotic resistant
b. Long-term immunity is not established after infection
c. It hides in neurons and reactivates, lysing cells
d. It is sexually transmitted
e. All of the above apply

Guida verificata passo dopo passo
1
Step 1: Understand the nature of chlamydia infection and the immune response it elicits. Chlamydia trachomatis is a bacterial pathogen that causes sexually transmitted infections.
Step 2: Consider the concept of immunity after infection. Some infections lead to long-lasting immunity, but others do not. Determine whether chlamydia infection results in long-term protective immunity.
Step 3: Evaluate the options given: (a) antibiotic resistance, (b) lack of long-term immunity, (c) latency in neurons, (d) mode of transmission, and (e) all of the above. Analyze which of these factors contribute to the possibility of reinfection.
Step 4: Recall that chlamydia does not establish latency in neurons like some viruses (e.g., herpes simplex virus), so option (c) is unlikely to be correct.
Step 5: Conclude that the main reason patients can contract chlamydia more than once is because long-term immunity is not established after infection, making option (b) the best explanation.

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Immunity and Reinfection

Some infections, like chlamydia, do not induce long-lasting immunity, meaning the immune system does not develop strong memory cells to prevent future infections. This allows patients to be reinfected multiple times after treatment or clearance of the initial infection.
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Immune Tolerance

Antibiotic Resistance

Antibiotic resistance occurs when bacteria evolve mechanisms to survive exposure to antibiotics. While some bacteria are resistant, chlamydia is generally susceptible to standard antibiotics, so resistance is not the main reason for repeated infections.
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ABC Transporters Provide Multidrug Resistance

Pathogen Latency and Reactivation

Certain pathogens, like herpesviruses, can hide in neurons and reactivate later, causing recurrent infections. Chlamydia does not establish latency in neurons, so reactivation from a hidden state is not a feature of its infection cycle.
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Introduction to Pathogenic Toxins
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