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Ch. 14 - Principles of Disease and Epidemiology
Tortora - Microbiology: An Introduction 14th Edition
Tortora14th EditionMicrobiology: An IntroductionISBN: 9780138200398Non è quello che usi tu?Cambia libro di testo
Capitolo 10, Problema 10

Use the following information to answer questions 8–10.
A Maryland woman was hospitalized with dehydration. V. cholerae and Plesiomonas shigelloides were isolated from the patient, who had neither traveled outside the United States nor eaten raw shellfish during the preceding month. The patient had attended a party before hospitalization. Two other people at the party had acute diarrheal illness and elevated levels of serum antibodies against Vibrio. Everyone at the party ate crabs and rice pudding with coconut milk. Crabs left over from this party were served at a second party. One of the people at the second party had onset of mild diarrhea; specimens from of these people were negative for vibriocidal antibodies.
The source of the disease was
a. Plesiomonas shigelloides.
b. crabs.
c. V. cholerae.
d. coconut milk.
e. rice.

Guida verificata passo dopo passo
1
Step 1: Identify the pathogens isolated from the patient. The problem states that both Vibrio cholerae and Plesiomonas shigelloides were isolated, so these are the potential causative agents.
Step 2: Analyze the epidemiological clues. The patient and two others at the first party had diarrheal illness and elevated serum antibodies against Vibrio, indicating exposure to Vibrio cholerae rather than Plesiomonas shigelloides.
Step 3: Consider the food items consumed at the party. Everyone ate crabs and rice pudding with coconut milk. Since the illness is linked to Vibrio cholerae, which is commonly associated with seafood, crabs are a likely source.
Step 4: Note that leftover crabs were served at a second party, where one person developed mild diarrhea but had no vibriocidal antibodies, suggesting no Vibrio cholerae infection in the second party attendees.
Step 5: Conclude that the most probable source of the disease is the crabs contaminated with Vibrio cholerae, based on the pathogen isolated, antibody evidence, and food exposure history.

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Pathogenicity and Transmission of Vibrio cholerae

Vibrio cholerae is a bacterium that causes cholera, characterized by severe diarrhea and dehydration. It is typically transmitted through contaminated water or food, especially seafood. Understanding its pathogenicity and common transmission routes helps identify likely sources in outbreaks.
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Introduction to Pathogenic Toxins

Role of Vibriocidal Antibodies in Diagnosis

Vibriocidal antibodies are immune proteins produced in response to Vibrio cholerae infection. Elevated serum levels indicate recent or ongoing infection, making them useful markers for confirming exposure and differentiating between infected and non-infected individuals.
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Antibodies

Epidemiological Investigation of Foodborne Outbreaks

Epidemiology involves tracing the source and spread of infections by analyzing patient histories, food consumption, and symptom patterns. Identifying common foods and exposure events among affected individuals helps pinpoint the outbreak source and implement control measures.
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Use the following information to answer questions 8–10.

A Maryland woman was hospitalized with dehydration. V. cholerae and Plesiomonas shigelloides were isolated from the patient, who had neither traveled outside the United States nor eaten raw shellfish during the preceding month. The patient had attended a party before hospitalization. Two other people at the party had acute diarrheal illness and elevated levels of serum antibodies against Vibrio. Everyone at the party ate crabs and rice pudding with coconut milk. Crabs left over from this party were served at a second party. One of the people at the second party had onset of mild diarrhea; specimens from of these people were negative for vibriocidal antibodies.

This is an example of

a. vehicle transmission.

b. airborne transmission.

c. transmission by fomites.

d. direct contact transmission.

e. healthcare-associated transmission.

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