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Ch. 16 - Innate Immunity: Nonspecific Defenses of the Host
Tortora - Microbiology: An Introduction 14th Edition
Tortora14th EditionMicrobiology: An IntroductionISBN: 9780138200398Non è quello che usi tu?Cambia libro di testo
Capitolo 12, Problema 3

If the following are placed in the order of occurrence, which would be the third step?
a. Diapedesis
b. Digestion
c. Formation of a phagosome
d. Formation of a phagolysosome
e. Margination

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1
First, understand the sequence of events in the process of phagocytosis, which is how immune cells like neutrophils or macrophages engulf and destroy pathogens.
Identify the initial steps where immune cells move toward the site of infection: margination (e) is when leukocytes move to the blood vessel walls, followed by diapedesis (a), where they squeeze through the vessel walls into the tissue.
Next, the immune cells encounter the pathogen and engulf it, leading to the formation of a phagosome (c), which is a vesicle containing the ingested particle.
After the phagosome forms, it fuses with a lysosome to create a phagolysosome (d), where digestive enzymes break down the pathogen.
Finally, digestion (b) occurs inside the phagolysosome, where the pathogen is degraded by enzymes.

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Phagocytosis is a cellular mechanism where immune cells engulf and destroy pathogens. It involves sequential steps including recognition, attachment, ingestion, and digestion of microbes, essential for innate immunity.
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Diapedesis and Margination

Margination is the process where white blood cells move toward the blood vessel walls, followed by diapedesis, where they squeeze through the vessel walls to reach infection sites. These steps precede phagocytosis.
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