How can the complement system cause endotoxic shock?
Ch. 16 - Innate Immunity: Nonspecific Defenses of the Host

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Ch. 16 - Innate Immunity: Nonspecific Defenses of the Host
Problema 3
Tortora 14th Edition
Ch. 16 - Innate Immunity: Nonspecific Defenses of the Host
Problema 3Capitolo 12, Problema 3
If the following are placed in the order of occurrence, which would be the third step?
a. Diapedesis
b. Digestion
c. Formation of a phagosome
d. Formation of a phagolysosome
e. Margination
Guida verificata passo dopo passo1
First, understand the sequence of events in the process of phagocytosis, which is how immune cells like neutrophils or macrophages engulf and destroy pathogens.
Identify the initial steps where immune cells move toward the site of infection: margination (e) is when leukocytes move to the blood vessel walls, followed by diapedesis (a), where they squeeze through the vessel walls into the tissue.
Next, the immune cells encounter the pathogen and engulf it, leading to the formation of a phagosome (c), which is a vesicle containing the ingested particle.
After the phagosome forms, it fuses with a lysosome to create a phagolysosome (d), where digestive enzymes break down the pathogen.
Finally, digestion (b) occurs inside the phagolysosome, where the pathogen is degraded by enzymes.

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Phagocytosis Process
Phagocytosis is a cellular mechanism where immune cells engulf and destroy pathogens. It involves sequential steps including recognition, attachment, ingestion, and digestion of microbes, essential for innate immunity.
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Steps of Phagocytosis
Diapedesis and Margination
Margination is the process where white blood cells move toward the blood vessel walls, followed by diapedesis, where they squeeze through the vessel walls to reach infection sites. These steps precede phagocytosis.
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3) Vasodilation
Phagosome and Phagolysosome Formation
After engulfing a pathogen, the immune cell forms a phagosome, a vesicle containing the microbe. This then fuses with a lysosome to form a phagolysosome, where digestive enzymes break down the pathogen.
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Formation & Breakdown of Polysaccharides
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e. none of the above
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