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Ch. 23 - Microbial Diseases of the Cardiovascular and Lymphatic Systems
Tortora - Microbiology: An Introduction 14th Edition
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Capitolo 19, Problema 9

List the causative agent and method of transmission of infectious mononucleosis.

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Identify the causative agent of infectious mononucleosis, which is a specific virus responsible for the disease.
Explain that the causative agent is the Epstein-Barr virus (EBV), a member of the herpesvirus family.
Describe the primary method of transmission, focusing on how the virus spreads from person to person.
Clarify that infectious mononucleosis is mainly transmitted through saliva, often called the 'kissing disease,' but it can also spread via other forms of close contact involving saliva.
Summarize that understanding both the causative agent (EBV) and its transmission route (saliva) is essential for grasping how infectious mononucleosis spreads and how to prevent it.

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Causative Agent of Infectious Mononucleosis

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), a member of the herpesvirus family. EBV infects B lymphocytes and epithelial cells, leading to the characteristic symptoms of the disease such as fever, sore throat, and lymphadenopathy.
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Method of Transmission

The Epstein-Barr virus is mainly transmitted through saliva, often called the 'kissing disease.' Transmission can also occur via sharing utensils, drinks, or exposure to respiratory secretions from an infected person.
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Pathogenesis and Clinical Features

After transmission, EBV infects B cells and triggers an immune response involving T cells, causing symptoms like fatigue, fever, and swollen lymph nodes. Understanding this helps link the causative agent and transmission to the disease's clinical presentation.
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