Domanda del libro di testo
Show how you would synthesize each compound, beginning with acetylene and any necessary additional reagents
(b)
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14. Synthetic Techniques
Alkynide Alkylation
Scelta multipla
Propose a synthesis for the following transformations:
A
1) H2/Lindlar's Catalyst
2) KMnO4, OH-, Δ / H+
3) NaBH4
4) CH3MgBr
B
1) LiAlH
2) CH3Cl
3) H2/Pt
C
1) NaNH2
2) CH3Br
3) H2/Lindlar's catalyst
D
1) O3, Me2S
2) EtLi / H3O+
3) LDA
Guida verificata passo dopo passo1
Identify the starting material and the target molecule. The starting material is an alkyne (ethyne) and the target molecule is a cyclopropene.
Recognize that the transformation involves converting a linear alkyne into a cyclic alkene, specifically a cyclopropene.
Consider the use of a strong base like NaNH2 to deprotonate the terminal alkyne, generating an acetylide ion.
Plan to perform a nucleophilic substitution reaction with an alkyl halide, such as CH3Br, to form a new carbon-carbon bond, extending the carbon chain.
Use a selective hydrogenation process, such as H2 with Lindlar's catalyst, to partially reduce the alkyne to a cis-alkene, which can then undergo cyclization to form the cyclopropene.
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