Skip to main content
Indietro

Innate Immunity I

I pulsanti di controllo sono stati cambiati in modalità "navigazione".
1/32

Termini in questo insieme (32)

  • The immune system must...

    1. Tolerate our own cells

    2. Selectively recognize and respond against pathogens

    3. Differentiate between harmless foreign bodies and harmful foreign bodies

  • What are the anatomic barriers? What is the purpose?

    Skin, mucosa, respiratory epithelium, intestine. CONTAINMENT

  • What are the important complement barriers? Is it specific?

    C3, defensins, RegIII. It is non-specific

  • What kind of immune cells are these? Macrophage, granulocytes, NK cells, epithelial cells

    Innate

  • What kind of immune cells are these? B, T, antibodies, clonal expansion

    Adaptive

  • Where does the Alternative Pathway begin? What does it bind to?

    C3, binds directly to pathogen.

  • What factors does the alternative pathway deal with?

    PBD

  • What does C3 split into?

    C3a and C3B

  • What does C3b do to C5?

    Cleaves it

  • What does C5 do?

    Binds to other C's and makes membrane attack complex.

  • What does C3a do?

    Attract phagocytes

  • What does C3b do?

    Tags pathogen for destruction

  • What is Mannose Binding Lectin known as? What does it do to pathogen?

    Opsonin. It coats pathogen and enhances phagocytosis.

  • What is C3b known as? What does it do to pathogen?

    Opsonin. It coats pathogen and enhances phagocytosis.

  • What is lectin?

    Soluble proteins

  • What are lectins produced by?

    Liver

  • What do lectins do?

    Recognize specific carbs on microbe surface

  • LECTIN: What does MBL do?

    Binds to mannose containing carbs on pathogen

  • LECTIN: What two things is MBL made of?

    MASP1 and MASP2

  • LECTIN: What MASP acts a convertase to split C4?

    MASP2

  • LECTIN: What C4 binds to pathogen surface? Which one is released?

    C4b. C4a is released.

  • LECTIN: What happens after C2 splits?

    C2a binds to the C4b that is bonded to pathogen surface.

  • LECTIN: What complex acts as C3 convertase?

    C4bC2a

  • What allows C3b to covalently bind to pathogen?

    The thioester bond of C3 or C3b becomes susceptible to nucleophilic attack.

  • What C's recruit phagocytes?

    C3a and C5a

  • What cells interact with things bound by C3b?

    Cells that have receptors for it like macrophages and neutrophils

  • What are cleavage products referred to as? What do they do?

    Anaphylotoxins. They meditate inflammation.

  • What does activated endothelium do?

    Recruit blood-borne leukocytes

  • What Factors inactivate free C3b?

    Facor H and I

  • INHIBITORS: What is DAF? What does it do?

    Decay accelerating factor. it dissociates C3 convertase on human cell

  • INHIBITORS: What is MCP? What does it do?

    Membrane cofactor protein. It dissociates C3 convertase and makes it susceptible to Factor I

  • What inhibits formation of MAC? How?

    CD59, by preventing C9 partaking in MAC formation.