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Innate Immunity II

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Termini in questo insieme (22)

  • What are the functions of immune cells?

    1. Recognize pathogens

    1. Become activated

    2. Communicate with other cells

    3. Coordinate response

  • What happens after bacteria triggers macrophage?

    Cytokines and chemokine release

  • What do cytokine and chemokine lead to?

    Vasodilation, inflammation

  • Where do macrophages reside?

    Within tissue

  • What do macrophages come from?

    Monocytes

  • What do macrophages function as? What do they release?

    Phagocytes. They release cytokines.

  • What do cytokines do?

    Mediate inflammation

  • Where are monocytes recruited? What do they do when recruited?

    Recruited into tissues then differentiated into macrophages.

  • What does neutrophil act as?

    Phagocyte

  • Where is neutrophil stored?

    Stored in the bone marrow, released when there is infection

  • When is neutrophil extracellular trap (NET) released?

    When neutrophil recognizes pathogen

  • What does the nuclear DNA of NET do?

    Entangles

  • What do the histones and defensins of NET do?

    Toxic to pathogen

  • What kind of tissue pathogen detection is dendritic cell important for?

    Mucosal and skin

  • What do receptors on immune sells bind to?

    PAMPs on the microbe

  • Where are PAMP receptors found in cells for extracellular PAMPS?

    Cell surface

  • Where are PAMP receptors found for PAMPS brought into vcell?

    Endosomes

  • Where are PAMP receptors found for intracellular pathogens?

    Cytoplasm

  • What do PAMP receptors induce?

    Phagocytosis and altered gene expression

  • What is an example of a signaling receptor?

    Toll-like receptor

  • What receptor detects foreign DNA within cytoplasm?

    cGas

  • What do all signal transduction pathways that are initiated by PAMP recognition lead to?

    Activation of genes to encode cytokines