The reason glucose is detected in the urine of individuals with uncontrolled diabetes mellitus is that __________.
A
glucose is secreted in the collecting ducts of diabetics
B
glucose is too large to be filtered by the nephron
C
glucose cannot be reabsorbed by the kidney
D
the transport maximum for glucose reabsorption has been exceeded
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1
Understand the role of the kidneys in glucose reabsorption: The kidneys filter blood, and glucose is initially filtered out of the blood into the renal tubules.
Learn about the transport maximum (Tm): The transport maximum is the maximum rate at which glucose can be reabsorbed from the renal tubules back into the bloodstream. This is due to the limited number of glucose transporters available in the renal tubules.
Recognize what happens when the transport maximum is exceeded: In individuals with uncontrolled diabetes mellitus, blood glucose levels are very high. When the amount of glucose filtered by the kidneys exceeds the transport maximum, not all glucose can be reabsorbed.
Identify the consequence of exceeding the transport maximum: The excess glucose that cannot be reabsorbed remains in the renal tubules and is excreted in the urine, leading to glucosuria (presence of glucose in urine).
Conclude why glucose is detected in the urine: The presence of glucose in the urine of individuals with uncontrolled diabetes mellitus is due to the fact that the transport maximum for glucose reabsorption has been exceeded, not because glucose is secreted or too large to be filtered.