The heart apex is inferior and angled to the left, causing the left lung to be smaller and the anterior view to show mostly the right ventricle.
Primary Function of the Heart
Generate the pressure needed to create a pressure gradient that drives blood flow throughout the body.
Heart as a Dual Pump
The heart has right and left sides that share inner ventricular walls; the right heart pumps blood to the lungs (pulmonary circuit), and the left heart pumps blood to the body (systemic circuit).
Generalized Blood Circuit Pattern
Blood flows from heart side → large arteries → small arteries → arterioles → capillary beds → venules → small veins → large veins → back to the heart.
SV is the amount of blood ejected during systole; ESV is the blood remaining in ventricles after contraction.
Intrinsic vs Extrinsic Regulation of Cardiac Output
Intrinsic maintains cardiac output via preload and contractility; extrinsic uses autonomic nervous system and hormones to adjust heart rate and strength.
Starling's Law of the Heart
The more the cardiac muscle is stretched during filling, the stronger the subsequent contraction.
Tunica Intima of Blood Vessels
Innermost layer with endothelium, subendothelium, and internal elastic lamina, directly contacting blood flow.
Tunica Media of Blood Vessels
Middle layer composed of smooth muscle and external elastic lamina, responsible for vessel constriction and elasticity.
Vasoconstriction and Vasodilation Control
Sympathetic nervous system releases norepinephrine causing vasoconstriction; vasodilation occurs by blocking sympathetic signals centrally.
Types of Capillaries
Continuous (tight junctions, nutrient exchange), fenestrated (holes for filtration), and sinusoidal (large openings for blood cells).
Autoregulation of Blood Flow
Tissues regulate their own blood flow via myogenic (stretch-induced vasoconstriction) and metabolic (vasodilation from low O2/high CO2) mechanisms.
Blood Pressure Gradient (ΔP)
Difference in pressure between two points; magnitude and direction determine blood flow strength and direction.
Resistance Factors in Blood Flow
Resistance increases as vessel radius decreases, blood viscosity increases, or vessel length increases.
Congestive Heart Failure Effects
Right side failure causes systemic edema; left side failure causes pulmonary edema and reduced oxygen delivery.
Baroreceptor Reflex in Blood Pressure Regulation
Baroreceptors detect pressure changes and adjust autonomic output to maintain blood pressure homeostasis.
Fetal Circulation Special Features
Includes ductus arteriosus, foramen ovale, and ductus venosus to bypass lungs and liver before birth.