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Anatomy & Physiology: Cell Membrane Structure and Transport

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  • What are the three basic parts of a human cell?

    Plasma membrane: flexible outer boundary, Cytoplasm: intracellular fluid with organelles, Nucleus: DNA-containing control center.

  • Describe the structure of the plasma membrane.

    A fluid mosaic model with a bilayer of phospholipids and embedded proteins, including cholesterol for stiffness.

  • What are the characteristics of phospholipids in the membrane?

    Phosphate heads are polar and hydrophilic, fatty acid tails are nonpolar and hydrophobic.

  • What roles do membrane proteins play?

    Functions include transport (channels/carriers), enzymes, receptors, motor proteins, and cell-to-cell connections.

  • What is selective permeability of the plasma membrane?

    Allows nutrients in, wastes out, and prevents many undesirable substances from entering due to its hydrophobic core.

  • Define simple diffusion across the plasma membrane.

    Movement of nonpolar, lipid-soluble substances like oxygen and carbon dioxide directly through the lipid bilayer down their concentration gradient.

  • What is facilitated diffusion?

    Passive transport of hydrophobic molecules with help from carrier or channel proteins down their concentration gradient.

  • How does carrier-mediated facilitated diffusion work?

    Specific molecules bind to transmembrane carriers which change shape to transport them across the membrane.

  • What are channel-mediated facilitated diffusion channels?

    Transmembrane proteins with aqueous cores that allow ions to pass based on size and charge; can be leakage or gated channels.

  • Explain osmosis in the context of the plasma membrane.

    Movement of water through a selectively permeable membrane via aquaporins, from low to high solute concentration.

  • What is tonicity and its effects on red blood cells?

    Isotonic: normal shape, Hypertonic: cell shrinks (crenation), Hypotonic: cell swells and may burst (lysis).

  • What distinguishes active membrane transport from passive transport?

    Active transport requires ATP energy to move solutes against their concentration gradient (low to high).

  • Describe the sodium-potassium pump function.

    Pumps 3 Na+ out and 2 K+ in using ATP, maintaining electrochemical gradients in excitable cells.

  • What is secondary active transport?

    Uses energy stored in ion gradients created by primary active transport to move other solutes indirectly.

  • What is vesicular transport?

    Movement of large substances across membranes inside vesicles, requiring ATP; includes endocytosis, exocytosis, and transcytosis.

  • What are the three types of endocytosis?

    Phagocytosis (cell eating), Pinocytosis (cell drinking), and Receptor-mediated endocytosis (selective uptake).

  • How does phagocytosis work?

    Cell forms pseudopods to engulf solid particles into a vesicle called a phagosome, used by macrophages.

  • What is pinocytosis?

    Non-specific uptake of extracellular fluid and solutes by plasma membrane infolding; no receptors involved.

  • Explain receptor-mediated endocytosis.

    Selective uptake where substances bind to specific membrane receptors before vesicle formation.

  • Describe exocytosis.

    Process where vesicles fuse with the plasma membrane to eject substances like hormones and neurotransmitters out of the cell.