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Anatomy & Physiology Core Concepts

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  • Define physiology

    Physiology is the study of the functions and processes of the body and its parts.

  • Principle of complementarity between anatomy and physiology

    Anatomy describes structure, while physiology explains function; structure and function are complementary.

  • Four major types of human body cells

    Epithelial, muscle, nerve, and connective tissue cells, each with distinct structure and function.

  • Body fluid compartments and water distribution

    Water is distributed mainly in intracellular fluid (~2/3) and extracellular fluid (~1/3), including plasma and interstitial fluid.

  • Define homeostasis

    Homeostasis is the maintenance of a stable internal environment despite external changes.

  • Elements of a control system

    Receptor, control center, and effector work together to maintain homeostasis.

  • Negative feedback in homeostasis

    Negative feedback reverses a change to maintain stability, e.g., thermoregulation and blood glucose control.

  • Positive feedback in homeostasis

    Positive feedback amplifies a change, e.g., blood clotting to quickly seal wounds.

  • Define chemical element and four major elements in the body

    A chemical element is a substance of one type of atom; major elements are oxygen, carbon, hydrogen, and nitrogen.

  • Compare ionic, covalent, and hydrogen bonds

    Ionic bonds transfer electrons; covalent bonds share electrons; hydrogen bonds are weak attractions between polar molecules.

  • Polar vs nonpolar compounds

    Polar compounds have unequal electron sharing and are hydrophilic; nonpolar compounds share electrons equally and are hydrophobic.

  • Structure and importance of water

    Water is a polar molecule with hydrogen bonds; it supports life by dissolving substances and regulating temperature.

  • Three major types of chemical reactions in physiology

    Synthesis (building molecules), decomposition (breaking down molecules), and exchange (swapping parts between molecules).

  • Monomers vs polymers

    Monomers are single units; polymers are chains of monomers linked together.

  • Four major biochemical groups and their monomers

    Carbohydrates (monosaccharides), lipids (fatty acids), proteins (amino acids), nucleic acids (nucleotides).

  • Four levels of protein structure and bonding

    Primary (peptide bonds), secondary (hydrogen bonds), tertiary (various bonds), quaternary (multiple polypeptides).

  • Define enzyme

    An enzyme is a protein that catalyzes biochemical reactions by lowering activation energy.

  • Effect of enzymes on reactions

    Enzymes speed up reactions without being consumed by lowering the activation energy needed.

  • Define substrate, active site, and specificity

    Substrate is the reactant; active site is the enzyme region binding substrate; specificity means enzymes act on specific substrates.

  • Role of cofactors and coenzymes in enzymatic function

    Cofactors (inorganic) and coenzymes (organic) assist enzymes in catalysis by stabilizing structure or participating in reactions.

  • Role of temperature and pH in enzymatic function

    Enzymes have optimal temperature and pH; deviations can denature enzymes and reduce activity.

  • Three major regions of a cell

    Plasma membrane, cytoplasm, and nucleus.

  • Basic structure of the cellular membrane

    A phospholipid bilayer with embedded proteins, cholesterol, and carbohydrates forming a selective barrier.

  • Integral vs peripheral proteins

    Integral proteins span the membrane; peripheral proteins attach to the membrane surface.

  • Three common types of cell junctions

    Tight junctions (seal cells), desmosomes (anchor cells), and gap junctions (allow communication).

  • Define metabolism and distinguish catabolic vs anabolic reactions

    Metabolism is all chemical reactions; catabolic reactions break down molecules; anabolic build molecules.

  • Role of ATP in energy metabolism

    ATP stores and transfers energy for cellular processes by releasing energy when hydrolyzed.

  • Explain selective permeability of plasma membrane

    The membrane allows some substances to pass while restricting others, maintaining internal environment.

  • Compare active and passive transport

    Passive transport moves substances down concentration gradients without energy; active transport requires energy to move substances against gradients.

  • Summarize the Na+/K+ pump

    An active transport protein that moves 3 Na+ out and 2 K+ into the cell, maintaining membrane potential.