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Anatomy & Physiology Key Concepts

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  • Atom

    Smallest stable unit of matter containing equal numbers of protons and electrons.

  • Atomic number

    Number of protons in an atom.

  • Mass number

    Total number of protons and neutrons in an atom.

  • Isotopes

    Atoms with the same number of protons but different numbers of neutrons.

  • Ionic bond

    Electrical attraction between cations and anions formed by transfer of electrons.

  • Covalent bond

    Bond formed by sharing electrons between atoms to form molecules.

  • Polar molecule

    Molecule with unequal sharing of electrons in covalent bonds, resulting in partial charges.

  • Enzymes

    Proteins that promote chemical reactions by lowering activation energy.

  • Anabolic reactions

    Metabolic processes that build up molecules.

  • Catabolic reactions

    Metabolic processes that break down molecules.

  • Levels of organization in the body

    Chemical, Cellular, Tissue, Organ, Organ system, Organism levels, each more complex than the last.

  • Cell Theory

    Cells are the structural building blocks of all plants and animals.

  • Primary tissue types

    Epithelial, Connective, Muscle, and Nervous tissues.

  • Epithelial tissue functions

    Provides physical protection, absorption, and secretion; covers body surfaces and lines cavities.

  • Exocrine glands

    Secrete substances onto external surfaces or into ducts.

  • Endocrine glands

    Secrete hormones into interstitial fluid.

  • Types of epithelial cell shapes

    Squamous (flat), Cuboidal (cube-shaped), Columnar (tall and slender).

  • Stratified squamous epithelium

    Multiple layers of cells providing protection; found on skin surface and lining mouth, throat, and vagina.

  • Connective tissue matrix components

    Protein fibers (collagen, elastic, reticular) and ground substance (liquid).

  • Types of cartilage

    Hyaline (stiff support), Elastic (flexible), Fibrocartilage (resists compression).

  • Compact bone

    Dense outer layer of bone that bears weight.

  • Spongy bone

    Internal bone layer with a fine network structure.

  • Integumentary system components

    Cutaneous membrane (epidermis and dermis), accessory structures (hair, nails, glands), and subcutaneous layer.

  • Epidermis

    Outer skin layer made of stratified squamous epithelium; lacks blood vessels.

  • Stratum corneum

    Outermost epidermal layer with 15–30 layers of keratinized cells; water resistant.

  • Positive feedback

    Feedback that amplifies a response and does not restore homeostasis, e.g., blood clotting.

  • Anatomical position

    Body standing upright, hands at sides, palms facing forward, feet together facing forward.

  • Frontal (coronal) plane

    Divides body into anterior (front) and posterior (back) parts.

  • Sagittal plane

    Divides body into right and left halves.

  • Transverse (horizontal) plane

    Divides body into upper and lower parts.

  • If you lose an electron


    You get fewer electrons then protons, more positive charge, cation

  • If you gain an electron


    More electrons then protons, more negative, anion

  • nerve cells


    wide surface for communication

  • Histology


     study of tissues

  • Matrix composed of


     Protein fibers and Ground substance (liquid)

  • Muscle tissue


    Can contract forcefully, support, maintenance, stabilization

  • Skeletal 


    Moves or stabilizes position of skeleton or internal organs

  • Cardiac


    Propels blood through blood vessels

  • Smooth


    Found in blood vessel walls, within glands, along respiratory, circulatory, digestive, and reproductive tracts

  • Neurons


    Transmit information in form of electrical impulses

  • Neuroglia


    support neurons

  • Hemidesmosomes


    Attach deepest epithelial cells to basement membrane

  • Reticular lamina


    Gives strength and restricts diffusion

  • Mesothelium


    lining ventral body cavities

  • Endothelium


    lining heart and blood vessels

  • Keratinized


    – Superficial layers packed with keratin

    – Tough and water resistant

    – Resists both mechanical stress and dehydration

    – Found on surface of skin and in hair and nails

  • Nonkeratinized


    – Resists abrasion but can dry out

    – Found lining oral cavity, pharynx, esophagus, anus, vagina

  • Simple cuboidal epithelium


    Does secretion and absorption

    Lines exocrine glands and ducts, Lines parts of kidney tubules and thyroid gland

  • Stratified cuboidal epithelium


    Found in ducts of sweat glands and mammary glands

  • Transitional epithelium (changes in appearance) 


    stratified epithelium that can stretch and recoil without damage

  • Pseudostratified columnar epithelium 


     Cells of varying shapes and functions and Lines nasal cavities, trachea, larger airways in lungs, portions of male

    reproductive tract

  • Apocrine secretion


    cell releases cytoplasm as well as secretory product

  • Holocrine secretion


    Destroys gland cells. Entire cell bursts, releasing secretions and killing cells. Destroyed cells replaced by stem cell division

  • Loose connective tissue


    (fibers create loose, open framework)

  • Areolar


    Packing material of the body

  • Adipose


    deep to skin in various areas of body, forms padding around eyes and kidneys

  • Reticular


    Provides support and resists distortion, Found in liver, kidney, spleen, lymph nodes, and bone marrow

  • Dense connective tissue


    (fibers densely packed)

  • Dense regular


    Found in cords (tendons, ligaments) or sheets, Collagen arranged in parallel bundles

  • Dense irregular


    Fibers arranged in meshwork (no consistent pattern) to resist

    tension in many directions, covering visceral organs; in superficial layers of bones, cartilages, and peripheral nerves; in dermis of skin

  • Elastic


     Is springy and resilient, Found between vertebrae, in walls of large blood vessels, erectile tissues of penis, ligaments supporting transitional epithelia

  • Connective tissue must have these three components 


    Fibers, ground substance, Maintenance, repair, and energy storage

  • Fibroblasts


     synthesize extracellular fibers

  • Adipocytes


     store lipid reserves

  • Fibrocytes


    differentiate from fibroblasts and maintain extracellular fibers

  • Hyaline cartilage


    Function: Provides stiff but flexible support and Reduces friction between bony surfaces

    Location: between ribs and sternum, covering bones in mobile joints,

    part of nasal septum, supporting respiratory passageways

  • Elastic cartilage


    Function: Distorts without damage and returns to original shape

    Location: Found in external ear and smaller internal structures

  • Fibrocartilage


    Function: Resists compression, prevents bone-to-bone contact, and limits

    relative movement

    Location: Found in knee joint, between pubic bones, and in intervertebral discs

  • Layers of  layers of perichondrium:


    Outer layer of dense irregular connective tissue

    Function: Mechanical support, protection, attachment

    Inner cellular layer

    Function: Where cartilage growth and maintenance occur

  • Cutaneous membrane


    Epidermis (stratified squamous epithelium) 

    Dermis (Reticular layer:  meshwork)

    Accessory structures 

    Hairs

    Nails

    Exocrine glands

    Cutaneous plexus (network of blood vessels)

  • Subcutaneous layer (hypodermis)


    Not apart of system

    Separates skin from deeper structures

  • Function of the Integumentary System


    Protect from abrasion, fluid loss, and chemical attack

    Excrete salts and water

    Body temp 

    Keratin 

    Detect stimuli 

    Store lipids

  • Basal cells


    stem cells that divide to replace more superficial keratinocytes

  • Stratum spinosum (“spiny layer”)


    8–10 layers of keratinocytes bound together by desmosomes

  • Stratum granulosum (“grainy layer”)


    3–5 layers of keratinocytes. Stopped dividing and started producing keratin. 

  • Stratum lucidum (“clear layer”)


    Found only in thick skin. Flattened, densely

    packed dead cells filled with keratin

  • Stratum corneum


    Stratum corneum~ Outermost, protective region with 15–30 layers of keratinized cells (filled with keratin). Water resistant 

    -Insensible perspiration (Unaware)

    -sensible perspiration (aware of sweat)

  • Basal cell carcinoma


     Most common form of skin cancer. Mutations caused by overexposure 

  • Malignant melanoma


     Extremely dangerous. Grow rapidly 

  • Tactile discs


    Detect texture and steady pressure

  • Lamellar


    Detect deep pressure and vibration

  • Ruffini corpuscles


    Sensitive to pressure and stretching of skin

  • Apocrine sweat glands


     Sticky, cloudy, odorous secretion