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Anatomy & Physiology Unit 1 Exam Study Guide

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  • Functions of blood

    Transport of gases, nutrients, wastes; regulation of pH, temperature, and water content; protection against blood loss and infection.

  • General composition of blood

    About 45% formed elements (cells) and 55% plasma (liquid). Changes in plasma volume or cell production alter these percentages.

  • Define hematocrit

    Percentage of blood volume occupied by red blood cells (RBCs). In dehydration, hematocrit increases; with RBC overproduction, hematocrit also increases.

  • Average normal blood volume in adults

    Approximately 5 liters total; about 2.25 L formed elements (45%) and 2.75 L plasma (55%).

  • Average RBC count and oxygen-carrying capacity

    About 5 million RBCs per µl of blood. RBC count directly relates to oxygen-carrying capacity because RBCs contain hemoglobin.

  • Anemia

    Condition caused by deficiency of RBCs or hemoglobin, leading to reduced oxygen delivery to tissues.

  • Average lifespan of RBC and fate of iron and porphyrin

    RBC lifespan is about 120 days. Iron is recycled; porphyrin is converted to bilirubin and excreted.

  • Average WBC and platelet counts

    WBCs: 5,000-10,000 per µl; platelets: 150,000-400,000 per µl. Leukopoiesis is the production of WBCs.

  • Meaning of '-cytosis' and '-penia'

    '-cytosis' means increased cell count; '-penia' means decreased cell count.

  • Leukopenia and leukocytosis

    Leukopenia: deficiency of leukocytes; leukocytosis: excessive leukocytes.

  • Components of hemoglobin molecule

    Four protein chains, four heme groups, and four iron atoms. The iron atoms bind oxygen.

  • Define serum, thrombus, embolus

    Serum: plasma without clotting factors; thrombus: blood clot in vessel; embolus: thrombus that has detached and travels in blood.

  • Difference between granulocytes and agranulocytes

    Granulocytes have visible granules (neutrophils, eosinophils, basophils); agranulocytes lack granules (lymphocytes, monocytes).

  • Functions of leukocytes

    Neutrophils: phagocytosis; eosinophils: combat parasites; basophils: release histamine; lymphocytes: immune response; monocytes: become macrophages.

  • Most abundant leukocytes and their percentages

    Neutrophils (~60-70%) and lymphocytes (~20-30%) make up most leukocytes.

  • Diapedesis

    Process of WBCs leaving the bloodstream and migrating into tissues.

  • Four major plasma proteins and their functions

    Albumin: maintains osmotic pressure; Globulins: immune functions; Fibrinogen: clotting; Regulatory proteins: enzymes and hormones.

  • Define hemostasis and its phases

    Hemostasis is stopping bleeding. Phases: vascular spasm, platelet phase, coagulation phase.

  • Coagulation cascades and triggers

    Extrinsic cascade triggered by tissue damage; intrinsic by blood contact with collagen; clotting occurs in the common pathway.

  • Platelet secretions in hemostasis

    Platelets secrete chemicals causing vasoconstriction and release calcium ions vital for clotting.

  • Erythropoiesis

    Production of RBCs triggered by low oxygen; occurs in red bone marrow; regulated by erythropoietin from kidneys.

  • Define hemocytoblast

    Multipotent stem cell in bone marrow that gives rise to all blood cells.

  • Thrombocytopenia, thromboembolism, hemophilia

    Thrombocytopenia: low platelet count; thromboembolism: clot blocking vessel; hemophilia: genetic clotting disorder.

  • Pathway of blood through the heart

    Right atrium → tricuspid valve → right ventricle → pulmonary valve → lungs → left atrium → mitral valve → left ventricle → aortic valve → body.

  • Heart valves dependent on papillary muscles and chordae tendineae

    Tricuspid and mitral (atrioventricular) valves depend on papillary muscles and chordae tendineae.

  • Two heart sounds and their causes

    "Lub" = AV valves closing; "Dub" = semilunar valves closing.

  • Components of cardiac conduction system

    SA node, AV node, AV bundle (Bundle of His), bundle branches, Purkinje fibers.

  • Pacemaker of the heart and its rate

    SA node; called pacemaker because it initiates heartbeat; fires at 60-100 impulses per minute.