Fluid, Electrolyte, and Acid-Base Homeostasis in Anatomy & Physiology
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The intracellular fluid (ICF) inside cells and the extracellular fluid (ECF) outside cells, which includes plasma and interstitial fluid. Together, they make up total body water.
ICF has high potassium (K+) and phosphate levels; ECF has high sodium (Na+) and chloride (Cl-) concentrations.
Osmotic pressure is generated by solute concentration differences across membranes, causing water to move toward higher solute concentrations.
Hydrostatic pressure pushes water out of capillaries; osmotic pressure pulls water into capillaries based on solute concentration.
Water is gained through ingestion (drinking and food) and metabolic water produced by cellular respiration.
Water is lost via urine, feces, insensible loss (skin and lungs), and sweat.
Thirst is regulated by the hypothalamus responding to increased plasma osmolarity and decreased blood volume.
Kidneys adjust urine volume and concentration under hormonal control, mainly by antidiuretic hormone (ADH).
Dehydration results from excessive water loss or insufficient intake; overhydration occurs from excess water intake or impaired excretion.
Electrolytes like Na+, K+, Ca2+, Cl-, and phosphate ions regulate fluid balance, nerve impulses, muscle contraction, and acid-base balance.
Hormones like aldosterone regulate Na+ and K+ levels; parathyroid hormone (PTH) regulates Ca2+ and phosphate.
PTH increases blood Ca2+ by releasing it from bone and decreases phosphate reabsorption, balancing their levels.
Blood pH depends on the balance of hydrogen ions (H+) and is maintained by buffer systems, respiratory control of CO2, and renal regulation of H+ and bicarbonate.
The bicarbonate buffer system, phosphate buffer system, and protein buffers help stabilize pH by binding or releasing H+.
Increased PCO2 raises H+ concentration, lowering pH; bicarbonate ions act as a base to neutralize H+, raising pH.
By adjusting breathing rate, the respiratory system controls CO2 levels, thus regulating blood pH; hyperventilation decreases CO2, raising pH.
Kidneys secrete H+ and reabsorb bicarbonate to correct pH imbalances, either acidifying or alkalinizing the blood.
Compensation is the body's adjustment via respiratory or renal mechanisms to correct respiratory or metabolic acidosis or alkalosis.
It adjusts blood pressure and flow to regulate fluid distribution and supports kidney function for electrolyte balance.
It secretes hormones like ADH, aldosterone, and PTH to regulate water retention and electrolyte levels.
By filtering blood, adjusting urine volume, and secreting or reabsorbing ions, the kidneys maintain fluid balance and acid-base homeostasis.