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Lymphatic System Anatomy & Physiology

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  • Functions of lymphatic vessels

    Transport excess interstitial fluid back to the bloodstream, absorb fats from the digestive tract, and filter pathogens through lymph nodes.

  • Structure of lymphatic vessels

    Thin-walled vessels with valves, similar to veins, that prevent backflow and ensure one-way lymph transport.

  • Distribution of lymphatic vessels

    Widely distributed throughout the body, especially in connective tissues and near blood capillaries.

  • Source of lymph

    Lymph originates from interstitial fluid that enters lymphatic capillaries.

  • Mechanisms of lymph transport

    Movement aided by skeletal muscle contractions, respiratory movements, and valves preventing backflow.

  • Basic structure of lymphoid tissue

    Composed of reticular connective tissue with a large population of lymphocytes and macrophages.

  • Cellular population of lymphoid tissue

    Includes B cells, T cells, and macrophages.

  • Diffuse lymphoid tissue

    Scattered lymphocytes without a defined structure, found in mucous membranes and organs.

  • Follicular lymphoid tissue

    Dense spherical clusters of lymphocytes called lymphoid follicles, often with germinal centers.

  • General location of lymph nodes

    Located along lymphatic vessels, especially in the neck, armpits, and groin.

  • Histological structure of lymph nodes

    Encapsulated with an outer cortex containing follicles and an inner medulla with cords and sinuses.

  • Functions of lymph nodes

    Filter lymph to remove pathogens and debris, and provide sites for lymphocyte activation.

  • Structure of the spleen

    Encapsulated organ with white pulp (lymphoid tissue) and red pulp (blood filtration).

  • Function of the spleen

    Filters blood, removes old red blood cells, and mounts immune responses.

  • Comparison: spleen vs lymph nodes

    Spleen filters blood; lymph nodes filter lymph. Both contain lymphocytes and macrophages for immune defense.

  • Definition of MALT

    Mucosa-associated lymphoid tissue is lymphoid tissue in mucous membranes protecting against pathogens.

  • Major components of MALT

    Includes tonsils, Peyer's patches in the intestines, and appendix lymphoid tissue.

  • Structure of the thymus

    Bi-lobed organ with an outer cortex and inner medulla, containing developing T cells.

  • Function of the thymus

    Site of T cell maturation and differentiation, essential for adaptive immunity.