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Muscle Tissue and Physiology - Anatomy & Physiology

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  • Contractility

    the ability of muscle cells to shorten forcefully, generating tension.

  • Excitability

    the ability of muscle cells to respond to stimuli by depolarizing their membrane.

  • Conductivity

    the ability of muscle cells to propagate an electrical signal along their membrane.

  • Distensibility

    the ability of muscle cells to stretch without damage.

  • Elasticity

    the ability of muscle cells to return to their original length after stretching.

  • Myocyte

    a muscle cell, also called a muscle fiber in skeletal muscle.

  • Sarcoplasm

    the cytoplasm of a muscle cell, containing organelles and myofibrils.

  • Sarcolemma

    the plasma membrane of a muscle cell that conducts action potentials.

  • Myofibril

    a cylindrical organelle composed of contractile proteins within muscle cells.

  • Sarcoplasmic Reticulum

    stores and releases calcium ions to trigger muscle contraction.

  • Compare skeletal, cardiac, and smooth muscle tissue

    Skeletal muscle is voluntary, striated, and attached to bones; cardiac muscle is involuntary, striated, and found in the heart; smooth muscle is involuntary, non-striated, and found in organs.

  • Transverse Tubule (T-tubule)

    invaginations of the sarcolemma that transmit action potentials deep into muscle fibers.

  • Myofilament

    contractile proteins actin (thin filament) and myosin (thick filament) within myofibrils.

  • Sarcomere

    the functional contractile unit of a myofibril, defined by Z discs.

  • Sliding Filament Mechanism

    describes how actin and myosin filaments slide past each other to shorten sarcomeres during contraction.

  • Function of sarcoplasmic reticulum

    regulates intracellular calcium levels by storing and releasing calcium ions.

  • Function of T-tubules

    conduct action potentials from the sarcolemma to the sarcoplasmic reticulum to trigger calcium release.

  • Triad composition

    A triad consists of one T-tubule flanked by two terminal cisternae of the sarcoplasmic reticulum.

  • Contractile, regulatory, and structural proteins in myofibrils

    Contractile proteins (actin, myosin) generate tension; regulatory proteins (troponin, tropomyosin) control contraction; structural proteins (titin) maintain filament alignment.

  • Myosin head binding sites

    The myosin head has an actin binding site for crossbridge formation and a myosin ATPase site for ATP hydrolysis.

  • Crossbridge

    the connection formed when the myosin head binds to the active site on actin during contraction.

  • Role of tropomyosin and troponin at low calcium

    At low calcium, tropomyosin blocks actin's active sites, and troponin holds tropomyosin in place, preventing crossbridge formation.

  • Role of tropomyosin and troponin at high calcium

    At high calcium, calcium binds to troponin, causing tropomyosin to move and expose actin's active sites for crossbridge formation.

  • Membrane potential

    Membrane potential is the voltage difference across a cell membrane due to ion distribution.

  • Resting membrane potential (RMP)

    the stable, negative membrane potential of a resting cell, typically around -70 mV in muscle cells.

  • Depolarization

    reduction of membrane potential as sodium ions enters the cell, making it more positive.

  • Repolarization

    the restoration of the negative membrane potential as potassium ions exit the cell.

  • Sodium-potassium pump function

    The sodium-potassium pump uses ATP to move 3 sodium ions out and 2 potassium ions into the cell, maintaining ion gradients.

  • Neuromuscular junction components

    The neuromuscular junction includes the motor neuron axon terminal, synaptic cleft, and motor end plate of the muscle fiber.

  • Function of acetylcholine (ACh)

    ACh is the neurotransmitter that binds receptors on the motor end plate to initiate muscle cell depolarization.

  • Role of acetylcholinesterase

    Acetylcholinesterase breaks down ACh in the synaptic cleft to terminate the signal and allow muscle relaxation.