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Tissue Injuries and Repair in Anatomy & Physiology

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  • What are the two stages of tissue response to injury?

    Inflammation (inflammatory response) and regeneration to restore normal function.

  • What can trigger the inflammatory response?

    Trauma (physical injury) and infection (presence of pathogens).

  • What do damaged cells release to initiate inflammation?

    Prostaglandins, proteins, and potassium ions.

  • What role do mast cells play in tissue injury?

    Damaged connective tissue activates mast cells which contribute to inflammation.

  • What are the four classic signs of inflammation?

    Redness, swelling, heat, and pain.

  • What happens during the process of inflammation at the cellular level?

    Lysosomes release enzymes that destroy injured cells and attack surrounding tissues.

  • What is necrosis in tissue injury?

    Tissue destruction that begins several hours after injury.

  • What accumulates in a wound after necrosis?

    Necrotic tissues and cellular debris (pus) accumulate.

  • What is an abscess?

    Pus trapped in an enclosed area within tissue.

  • Which tissues regenerate well after injury?

    Epithelia, connective tissues (except cartilage), and smooth muscle regenerate well.

  • Which tissues regenerate poorly or not at all?

    Skeletal muscle, cardiac muscle, and nervous tissues regenerate poorly or not at all.

  • How are damaged cardiac muscle cells repaired?

    They are replaced by fibrous tissue through fibrosis.

  • What do fibroblasts produce at the injury site?

    Collagen fibers to stabilize the injury site.

  • What is scar tissue?

    A dense, collagenous framework produced by fibroblasts during tissue repair.

  • What usually happens to scar tissue over time?

    It is remodeled and normal tissue conditions are restored.