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Chapter 3 lecture part 3
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What are the monomers and polymers of nucleic acids?
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What are the monomers and polymers of nucleic acids?
Monomer:
nucleotide;
Polymer:
nucleic acid (DNA and RNA)
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이 집합의 용어 (20)
하이드의 정의
What are the monomers and polymers of nucleic acids?
Monomer:
nucleotide;
Polymer:
nucleic acid (DNA and RNA)
What are the three components of a nucleotide?
Nitrogenous base, sugar (deoxyribose in DNA, ribose in RNA), and phosphate group
Name the nitrogenous bases found in DNA and RNA.
DNA: Adenine (A), Thymine (T), Cytosine (C), Guanine (G); RNA: Adenine (A), Uracil (U), Cytosine (C), Guanine (G)
How do deoxyribose and ribose sugars differ?
Deoxyribose has a 2'-H; ribose has a 2'-OH group
What type of bond links nucleotides in a polynucleotide chain?
Phosphodiester bond
between the 3' carbon of one sugar and the phosphate group of the next
Describe the directionality of DNA strands.
DNA strands are antiparallel: one runs 5'→3', the other 3'→5'
What bases pair together in DNA and by what type of bond?
Adenine pairs with Thymine; Guanine pairs with Cytosine via
hydrogen bonds
Why can't adenine pair with guanine or cytosine with thymine?
Because base pairing occurs only between a purine and a pyrimidine, maintaining consistent DNA width
Which base pair is stronger, G-C or A-T, and why?
G-C base pairs are stronger because they form three hydrogen bonds, while A-T pairs form two
What is the structure of DNA?
Double helix formed by two antiparallel polynucleotide strands wound into a spiral
How does RNA structure differ from DNA?
RNA is typically single stranded and contains ribose sugar and uracil instead of thymine
What are the three main types of RNA?
mRNA (messenger RNA), rRNA (ribosomal RNA), and tRNA (transfer RNA)
What is the role of nucleic acids in gene expression?
DNA directs RNA synthesis; RNA controls protein synthesis
What is the sugar-phosphate backbone in nucleic acids?
A repeating chain of sugar and phosphate groups linked by phosphodiester bonds
What is the complementary DNA strand to 5'-ATCGTGAC-3'?
5'-GTCACGAT-3'
What is the complementary RNA sequence to 5'-ATCGTGAC-3'?
5'-GUCACGAU-3'
What functional groups are found in nitrogenous bases?
Amino and keto groups that participate in hydrogen bonding
What type of bond forms between the sugar and phosphate group in nucleotides?
Phosphodiester bond
What is the significance of the 5' and 3' ends in DNA strands?
5' end has a phosphate group; 3' end has a hydroxyl group; directionality is critical for replication and transcription
How does base pairing contribute to DNA's function?
Ensures accurate replication and stable double helix structure through complementary hydrogen bonding