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General Biology: Introduction to Metabolism

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  • Energy

    Energy is the ability to perform work, which in biology means causing an overall change or transfer of energy.
  • Potential Energy

    Potential energy is stored energy available to do work, such as chemical energy in bonds.
  • Kinetic Energy

    Kinetic energy is energy of motion, like moving objects or muscle contractions.
  • Thermodynamics

    The study of energy transfers between systems and surroundings, where a system is the matter under study and surroundings is everything else.
  • First Law of Thermodynamics

    Energy cannot be created or destroyed, only transferred or transformed; total energy in the universe is constant.
  • Entropy

    A measure of disorder or randomness; higher disorder means higher entropy. Natural reactions tend to increase universal entropy.
  • Second Law of Thermodynamics

    Energy transfer is never 100% efficient; some energy is lost as heat, increasing the entropy of the universe.
  • Chemical Reaction

    Process involving the making and breaking of chemical bonds, converting reactants into products.
  • Endergonic Reaction

    A reaction that requires an input of energy to proceed (energy enters the reaction).
  • Exergonic Reaction

    A reaction that releases energy as it proceeds (energy exits the reaction).
  • ATP (Adenosine Triphosphate)

    A high-energy molecule composed of adenine, ribose sugar, and three phosphate groups; powers cellular activities.
  • ATP Hydrolysis

    The process of breaking bonds between phosphate groups in ATP, releasing energy and producing ADP.
  • Energy Coupling

    Using energy released from an exergonic reaction (like ATP hydrolysis) to drive an endergonic reaction.
  • Phosphorylation

    The transfer of a phosphate group from ATP to another molecule, often activating or changing the target molecule.
  • Enzyme

    A molecule that catalyzes chemical reactions by lowering activation energy without being consumed.
  • Substrate

    The reactant molecule that binds to an enzyme's active site for catalysis.
  • Activation Energy (EA)

    The minimum energy required to start a chemical reaction by reaching the transition state.
  • How Enzymes Work

    Enzymes lower the activation energy barrier, allowing reactions to proceed faster and at lower temperatures.
  • Enzyme-Substrate Complex

    The temporary complex formed when a substrate binds to an enzyme's active site.
  • Competitive Inhibition

    An inhibitor competes with the substrate for binding at the enzyme's active site, blocking substrate binding.
  • Noncompetitive Inhibition

    An inhibitor binds to an allosteric site, changing enzyme shape and reducing activity without blocking the active site.
  • Metabolism

    The total of an organism's chemical reactions, including metabolic pathways that alter substrates stepwise.
  • Catabolic Pathways

    Metabolic pathways that release energy by breaking down complex molecules into smaller ones.
  • Anabolic Pathways

    Metabolic pathways that consume energy to build larger molecules from smaller ones.
  • Negative Feedback

    When the final product of a metabolic pathway inhibits an earlier step to regulate the pathway.
  • Positive Feedback

    When the final product of a metabolic pathway stimulates an earlier step, enhancing the pathway's activity.