교과서 질문
Answer the following questions concerning the accuracy of DNA polymerase during replication.
If a DNA replication error is detected by DNA polymerase, how is it corrected?
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Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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TOC.tableOfContents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
11장, 문제 13d
Answer the following questions concerning the accuracy of DNA polymerase during replication.
Identify two mechanisms that can correct the kind of abnormality resulting from the circumstances identified in part (c).
검증된 단계별 안내1
Understand the role of DNA polymerase in replication: DNA polymerase is responsible for synthesizing new DNA strands by adding nucleotides complementary to the template strand. It has a proofreading ability to ensure accuracy during replication.
Learn about the proofreading mechanism: DNA polymerase has 3' to 5' exonuclease activity, which allows it to remove incorrectly paired nucleotides immediately after they are added. This mechanism significantly reduces the error rate during replication.
Explore mismatch repair: If an error escapes the proofreading activity of DNA polymerase, mismatch repair enzymes can identify and correct mismatched base pairs. These enzymes recognize distortions in the DNA helix caused by mismatches, excise the incorrect segment, and replace it with the correct sequence.
Understand the role of post-replication repair: In cases where errors persist after replication, post-replication repair mechanisms, such as homologous recombination, can resolve abnormalities by using the undamaged sister chromatid as a template to repair the DNA.
Review the importance of these mechanisms: Both proofreading by DNA polymerase and mismatch repair are essential for maintaining genomic stability and preventing mutations that could lead to diseases such as cancer.
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이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.
영상 길이:
2m주요 개념
질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.
DNA Polymerase Function
DNA polymerase is an enzyme responsible for synthesizing new DNA strands during replication. It adds nucleotides to a growing DNA chain by matching them with the template strand. While it has a high fidelity rate, errors can occur, necessitating correction mechanisms to maintain genetic integrity.
추천 영상:
가이드 코스
08:26
Functional Genomics
Proofreading Mechanism
Proofreading is a critical function of DNA polymerase that allows it to detect and correct mismatched nucleotides during DNA synthesis. This process involves the enzyme's 3' to 5' exonuclease activity, which removes incorrectly paired nucleotides, ensuring that the newly synthesized DNA is accurate.
추천 영상:
가이드 코스
02:35Proofreading
Mismatch Repair System
The mismatch repair system is a post-replication repair mechanism that identifies and corrects errors that escape the proofreading activity of DNA polymerase. This system involves several proteins that recognize mismatches, excise the erroneous segment, and fill in the correct nucleotides, thereby preserving genomic stability.
추천 영상:
가이드 코스
05:44Repair Pathways
관련 실천
교과서 질문
Answer the following questions concerning the accuracy of DNA polymerase during replication.
If a replication error escapes detection and correction, what kind of abnormality is most likely to exist at the site of the replication error?
438
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교과서 질문
Answer the following questions concerning the accuracy of DNA polymerase during replication.
If the kind of abnormality identified in part (c) is not corrected before the next DNA replication cycle, what kind of mutation occurs?
421
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교과서 질문
Several types of mutation are identified and described. These include (1) promoter mutation, (2) splice site mutation, (3) missense mutation, (4) frameshift mutation, and 5) nonsense mutation. Match the following mutation descriptions with the type(s) of mutations listed above. More than one mutation type might match a description.
A mutation that changes several amino acids in a protein and results in a protein that is shorter than the wild-type product.
849
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교과서 질문
Answer the following questions concerning the accuracy of DNA polymerase during replication.
What general mechanism do DNA polymerases use to check the accuracy of DNA replication and identify errors during replication?
500
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교과서 질문
Answer the following questions concerning the accuracy of DNA polymerase during replication.
DNA mismatch repair can accurately distinguish between the template strand and the newly replicated strand of a DNA duplex. What characteristic of DNA strands is used to make this distinction?
458
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