검증된 단계별 안내
07:10
07:56
10:05Cohesion between sister chromatids, as well as tension created by the pull of kinetochore microtubules, is essential to ensure efficient separation of chromatids at mitotic anaphase or in meiotic anaphase II. Explain why sister chromatid cohesion is important, and discuss the role of the proteins cohesin and separase in sister chromatid separation.
For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop.
What is the genotype of a normal cell in the retina in a person who has sporadic retinoblastoma? What is the normal cell genotype if the person has hereditary retinoblastoma? Explain the reason for the difference between the genotypes.
Our closest primate relative, the chimpanzee, has a diploid number of 2n = 48. For each of the following stages of M phase, identify the number of chromosomes present in each cell.
Early mitotic prophase
For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop.
Using RB1⁺ for the normal wild-type allele and RB1⁻ for the mutant allele, identify the genotype of a cell in a retinoblastoma tumor.
Our closest primate relative, the chimpanzee, has a diploid number of 2n = 48. For each of the following stages of M phase, identify the number of chromosomes present in each cell.
Early prophase I
Our closest primate relative, the chimpanzee, has a diploid number of 2n = 48. For each of the following stages of M phase, identify the number of chromosomes present in each cell.
Mitotic metaphase
