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Ch. 9 - The Molecular Biology of Translation
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172당신이 사용하는 게 아니라요?교과서 변경
모든 교과서Sanders 3rd EditionCh. 9 - The Molecular Biology of Translation문제 B.6b
9장, 문제 B.6b

A couple and some of their relatives are screened for Gaucher disease in a community-based screening program. The woman is homozygous for the dominant allele, represented by G. The woman's father, sister, and paternal grandmother are heterozygous carriers of the mutant allele, represented by g. Her paternal grandfather, her mother, and both of her mother's parents are homozygous for the dominant allele. The man is heterozygous and he has a brother with Gaucher disease. The man's parents and grandparents have not been tested, but it is known that none of them has Gaucher disease.
On the pedigree, write the genotypes (GG, Gg, or gg) for each person who has been tested or for whom you can deduce a genotype. If a genotype cannot be determined completely, list the alleles you know or deduce must be present.

검증된 단계별 안내
1
Identify the alleles involved: G is the dominant normal allele, and g is the recessive mutant allele causing Gaucher disease. Individuals with genotype gg have the disease, Gg are carriers, and GG are unaffected non-carriers.
Start with the woman: she is homozygous dominant (GG), so both her alleles are G. This means she inherited one G allele from each parent.
Analyze the woman's family: her father, sister, and paternal grandmother are heterozygous carriers (Gg), so each has one G and one g allele. Her paternal grandfather, mother, and maternal grandparents are homozygous dominant (GG). Use this information to assign genotypes to these individuals.
Consider the man: he is heterozygous (Gg), so he carries one G and one g allele. Since he has a brother with Gaucher disease (gg), both parents must carry at least one g allele, even though they are not tested and do not have the disease themselves (implying they are likely Gg).
For any individuals without direct test results, use Mendelian inheritance rules and the known genotypes of their relatives to deduce possible genotypes or at least the alleles they must carry. If a genotype cannot be fully determined, list the alleles that must be present based on inheritance.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.
영상 길이:
3m

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Mendelian Inheritance and Allele Dominance

Mendelian inheritance explains how alleles are transmitted from parents to offspring following dominant and recessive patterns. A dominant allele (G) masks the effect of a recessive allele (g) in heterozygotes. Understanding which alleles are dominant or recessive helps predict genotypes and phenotypes in pedigrees.
추천 영상:
가이드 코스
04:37
Variations on Dominance

Carrier Status and Genotype Deduction

Carriers are individuals who possess one copy of a recessive mutant allele (g) but do not show disease symptoms due to the presence of a dominant normal allele (G). By analyzing family relationships and known genotypes, one can deduce unknown genotypes based on inheritance patterns and the presence or absence of disease.
추천 영상:
가이드 코스
07:52
Gamete Genotypes

Pedigree Analysis and Genotype Assignment

Pedigree analysis involves mapping family relationships and phenotypes to infer genotypes. Using information about affected individuals and carriers, genotypes can be assigned or partially deduced for relatives. This method is essential for understanding genetic risks and inheritance in families.
추천 영상:
가이드 코스
01:59
Pedigree Flowchart
관련 실천
교과서 질문

Identify the amino acid carried by tRNAs with the following anticodon sequences.

5′-UAG-3′

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Describe three features of tRNA molecules that lead to their correct charging by tRNA synthetase enzymes.

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교과서 질문

Identify the amino acid carried by tRNAs with the following anticodon sequences.

5′-AAA-3′

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교과서 질문

A couple and some of their relatives are screened for Gaucher disease in a community-based screening program. The woman is homozygous for the dominant allele, represented by G. The woman's father, sister, and paternal grandmother are heterozygous carriers of the mutant allele, represented by g. Her paternal grandfather, her mother, and both of her mother's parents are homozygous for the dominant allele. The man is heterozygous and he has a brother with Gaucher disease. The man's parents and grandparents have not been tested, but it is known that none of them has Gaucher disease.

Explain why you are able to assign genotypes to the man's parents despite their not being tested.

388
views
교과서 질문

A couple and some of their relatives are screened for Gaucher disease in a community-based screening program. The woman is homozygous for the dominant allele, represented by G. The woman's father, sister, and paternal grandmother are heterozygous carriers of the mutant allele, represented by g. Her paternal grandfather, her mother, and both of her mother's parents are homozygous for the dominant allele. The man is heterozygous and he has a brother with Gaucher disease. The man's parents and grandparents have not been tested, but it is known that none of them has Gaucher disease.

Draw a pedigree of this family, including the woman, the man, their siblings, parents, and grandparents.

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교과서 질문

Identify the amino acid carried by tRNAs with the following anticodon sequences.

5′-CUC-3′

508
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