객관식
True or False? The process of affinity maturation generates antibodies with an increasing capacity to bind antigens and thus to more efficiently bind to, neutralize, and eliminate microbes.
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21. The Immune System
Affinity Maturation
객관식
How does an antibody’s ability to bind an antigen increase as B cells multiply?
A
Genetic rearrangement of the DNA encoding the antibody’s constant region occurs with each B cell generation.
B
Genetic mutations of the DNA encoding the antibody’s variable region occur with each B cell generation.
C
Variation in the amino acid sequence of the antibody stem occurs & allows the antibody to bind various antigens.
D
Genetic mutations of the DNA encoding the antibody occur changing the antibody into a BCR.
검증된 단계별 안내1
Understand the role of B cells in the immune response: B cells are a type of white blood cell that produce antibodies to bind specific antigens.
Recognize the importance of the antibody's variable region: The variable region of an antibody is responsible for binding to specific antigens. This region is highly specific and varies between different antibodies.
Learn about somatic hypermutation: As B cells multiply, they undergo a process called somatic hypermutation, which introduces genetic mutations in the DNA encoding the antibody's variable region. This increases the diversity of antibodies and enhances their ability to bind to antigens.
Distinguish between the variable and constant regions: The constant region of an antibody does not change during B cell multiplication. It is the variable region that undergoes genetic mutations to improve antigen binding.
Conclude with the correct mechanism: The increase in an antibody's ability to bind an antigen as B cells multiply is due to genetic mutations in the DNA encoding the antibody's variable region, enhancing the specificity and affinity of the antibody for its target antigen.
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