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Anatomy & Physiology: Blood, Cardiovascular, Respiratory, Urinary, and Fluid Balance

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  • Major components of blood

    Plasma, red blood cells, white blood cells, and platelets.

  • Describe a red blood cell

    Small, biconcave, anucleate cells specialized for oxygen transport using hemoglobin.

  • Function of hemoglobin

    Transports oxygen from lungs to tissues and carries some carbon dioxide back to lungs.

  • Metabolic pathway erythrocytes use to produce ATP

    Glycolysis (anaerobic metabolism) since they lack mitochondria.

  • Where are red blood cells produced?

    In the red bone marrow through a process called erythropoiesis.

  • How is red blood cell production controlled?

    By the hormone erythropoietin, released mainly by the kidneys in response to low oxygen.

  • Why is iron required for red blood cell formation?

    Iron is essential for hemoglobin synthesis, enabling oxygen binding.

  • Vitamins necessary for red blood cell production

    Vitamin B12 and folic acid are required for DNA synthesis in RBC precursors.

  • What is anemia?

    A condition characterized by a decrease in red blood cells or hemoglobin, reducing oxygen delivery.

  • What happens to damaged red blood cells?

    They are phagocytized mainly by macrophages in the spleen and liver.

  • Products of hemoglobin breakdown

    Heme is broken down into bilirubin and iron; globin is recycled into amino acids.

  • Distinguish granulocytes and agranulocytes

    Granulocytes have visible granules (neutrophils, eosinophils, basophils); agranulocytes do not (lymphocytes, monocytes).

  • Most active phagocytic white blood cells

    Neutrophils and monocytes are the primary phagocytes.

  • Functions of blood platelets

    Help in hemostasis by forming platelet plugs and releasing clotting factors.

  • Three types of plasma proteins and their functions

    Albumins maintain osmotic pressure, globulins transport and immune functions, fibrinogens aid clotting.

  • How albumins maintain water balance

    By exerting colloid osmotic pressure that draws water into blood vessels.

  • Role of fibrinogens

    Converted to fibrin during clotting to form a mesh that stabilizes blood clots.

  • What is hemostasis?

    The process that stops bleeding through vascular spasm, platelet plug formation, and coagulation.

  • Difference between extrinsic and intrinsic clotting mechanisms

    Extrinsic is triggered by external tissue damage; intrinsic is activated by blood contact with damaged endothelium.

  • Last two steps of the clotting cascade

    Conversion of prothrombin to thrombin, then fibrinogen to fibrin to form the clot.

  • Function of antithrombin

    Inhibits thrombin and other clotting factors to prevent excessive clotting.

  • Difference between antigens and antibodies

    Antigens are molecules on cell surfaces that trigger immune response; antibodies are proteins that bind to antigens.

  • Why is AB blood the universal recipient?

    Because it has no anti-A or anti-B antibodies, so it accepts all blood types.

  • Why is type O blood the universal donor?

    Because it has no A or B antigens, so it can be given to any blood type.

  • Distinguish pulmonary and systemic circuits

    Pulmonary circuit carries blood between heart and lungs; systemic circuit carries blood between heart and body tissues.

  • Function of the cardiac conduction system

    Generates and conducts electrical impulses to coordinate heartbeats.

  • What causes heart sounds?

    Closing of heart valves during the cardiac cycle produces the lub-dub sounds.

  • How is cardiac output calculated?

    Cardiac output = \(\text{heart rate} \times \text{stroke volume}\).

  • Describe the structure of the respiratory membrane

    Thin barrier of alveolar and capillary walls allowing gas exchange by diffusion.

  • How is oxygen transported from lungs to body cells?

    Mostly bound to hemoglobin in red blood cells; a small amount dissolved in plasma.

  • Describe the structure of a nephron

    Functional kidney unit consisting of the glomerulus, Bowman's capsule, proximal tubule, loop of Henle, distal tubule, and collecting duct.

  • What is tubular secretion?

    Active transport of substances from blood into the nephron tubules for excretion.

  • How does aldosterone regulate sodium and potassium?

    Increases sodium reabsorption and potassium secretion in the distal tubules.

  • How does the respiratory system help regulate acid-base balance?

    By controlling CO2 levels through breathing rate, affecting blood pH.