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Digestive System and Metabolism - Anatomy & Physiology

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  • Functions of the digestive system

    Ingestion: taking in food
    Digestion: breaking food into nutrient molecules
    Absorption: movement of nutrients into the bloodstream
    Defecation: excretion of indigestible waste

  • Two main groups of digestive system organs

    Alimentary canal: continuous, coiled hollow tube for ingestion, digestion, absorption, defecation
    Accessory digestive organs: teeth, tongue, and large digestive organs that assist digestion

  • Layers of tissue in alimentary canal organs

    From innermost to outermost: mucosa, submucosa, muscularis externa, and serosa

  • Mucosa layer composition

    Innermost moist membrane with surface epithelium (mostly simple columnar), lamina propria connective tissue, and a scant smooth muscle layer lining the lumen

  • Muscularis externa structure

    Smooth muscle with an inner circular layer and an outer longitudinal layer responsible for peristalsis

  • Role of the stomach in digestion

    Stores food, mixes it with gastric juice, initiates protein digestion, and delivers chyme to the small intestine

  • Gastric glands secrete

    Intrinsic factor for vitamin B12 absorption, hydrochloric acid to activate enzymes, pepsinogen for protein digestion, mucus, and local hormones like gastrin

  • Small intestine subdivisions

    Duodenum, jejunum, and ileum ending at the ileocecal valve

  • Structural modifications of the small intestine for absorption

    Villi with capillaries and lacteals, microvilli forming brush border enzymes, and circular folds (plicae circulares)

  • Functions of bile

    Produced by the liver, bile emulsifies fats to aid digestion and absorption of fats and fat-soluble vitamins

  • Role of the pancreas in digestion

    Produces digestive enzymes for all food categories and secretes alkaline fluid to neutralize acidic chyme in the duodenum

  • Phases of swallowing

    Buccal phase: voluntary, food formed into bolus and pushed to pharynx
    Pharyngeal-esophageal phase: involuntary, peristalsis moves bolus to stomach

  • Peristalsis

    Alternating waves of contraction and relaxation of muscularis externa that propel food through the digestive tract

  • Mechanical digestion examples

    Chewing in the mouth, churning in the stomach, and segmentation in the small intestine mixing food with digestive juices

  • Chemical digestion

    Enzymatic breakdown of large molecules into building blocks: carbohydrates to monosaccharides, proteins to amino acids, fats to fatty acids and glycerol

  • Absorption in the digestive system

    End products of digestion enter mucosal cells and then blood or lymph capillaries for distribution

  • Large intestine functions

    Absorbs water, vitamins, and ions; houses bacteria that produce vitamin K and B vitamins; forms and eliminates feces

  • Teeth classification by function

    Incisors: cutting
    Canines: tearing
    Premolars and molars: crushing and grinding

  • Saliva components and functions

    Mixture of mucus and serous fluids that moistens food, contains salivary amylase to begin starch digestion, and has lysozymes and antibodies to inhibit bacteria

  • Metabolism definition

    All chemical reactions necessary to maintain life, including catabolism (breaking down molecules to release energy) and anabolism (building larger molecules)

  • Three main metabolic pathways of cellular respiration

    Glycolysis in cytosol, citric acid cycle in mitochondria, and electron transport chain producing most ATP

  • Role of the liver in metabolism

    Manufactures bile, detoxifies substances, produces blood proteins, regulates blood glucose via glycogenesis, glycogenolysis, and gluconeogenesis

  • LDL vs HDL cholesterol

    LDL transports cholesterol to body cells and is considered 'bad' lipoprotein
    HDL transports cholesterol from cells to liver for breakdown and is 'good'

  • Basic metabolic rate (BMR)

    Heat produced by the body at rest, influenced by surface area, gender, age, and thyroxine levels

  • Body temperature regulation

    Controlled by hypothalamus; heat loss via radiation and sweating; heat production via vasoconstriction and shivering

  • Defecation reflex

    Triggered by feces in rectum causing relaxation of internal anal sphincter and voluntary relaxation of external anal sphincter to allow feces elimination