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Neurologic & Musculoskeletal System - Anatomy & Physiology Study Guide

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  • Central Nervous System (CNS)

    The CNS is composed of the brain and spinal cord. The brain processes and responds to information, while the spinal cord transmits signals and mediates reflexes.

  • Meninges

    Protective layers around the brain and spinal cord: dura mater (outer), arachnoid (middle), and pia mater (inner).

  • Cerebrospinal Fluid (CSF)

    Fluid circulating in the CNS that provides cushioning and nutrient transport. Normal CSF is clear; cloudy CSF suggests infection.

  • Blood-Brain Barrier

    A selective barrier that restricts passage of substances from blood to brain tissue, protecting neural tissue from toxins and pathogens.

  • Brainstem Functions

    Controls vital functions such as heart rate and breathing.

  • Difference between Afferent and Efferent Pathways

    Afferent nerves carry sensory information to the CNS; efferent nerves carry motor commands from the CNS to muscles.

  • Myelinated vs. Unmyelinated Nerve Fibers

    Myelinated fibers conduct impulses rapidly; unmyelinated fibers conduct impulses more slowly.

  • Role of Acetylcholine

    Acetylcholine is an excitatory neurotransmitter important for neuromuscular activity.

  • Sympathetic Nervous System Effects

    Activates the "fight or flight" response: increases heart rate, blood pressure, blood glucose; dilates pupils; inhibits digestion.

  • Parasympathetic Nervous System Effects

    Activates the "rest and digest" response: slows heart rate, promotes digestion, and supports healing.

  • Progression of Decreased Level of Consciousness

    Confusion → Disorientation → Memory loss → Lethargy → Coma.

  • Cushing Triad Components

    Signs of increased intracranial pressure: widening pulse pressure, bradycardia, and irregular/decreased respirations.

  • Contraindication for Lumbar Puncture

    Do not perform if increased intracranial pressure (ICP) is suspected due to risk of brain herniation.

  • Transient Ischemic Attack (TIA)

    Temporary loss of blood flow to the brain with symptoms that resolve; serves as a warning sign for stroke.

  • Signs of Meningitis

    Headache, neck stiffness (nuchal rigidity), fever, photophobia, positive Kernig and Brudzinski signs, and cloudy CSF.

  • Skull Fracture Signs

    Raccoon eyes, Battle sign, and CSF leak from ears or nose (otorrhea/rhinorrhea).

  • Definition of Quadriplegia

    Paralysis affecting all four limbs.

  • Autonomic Dysreflexia

    Life-threatening hypertension triggered by stimuli below a spinal cord injury; requires immediate removal of the trigger.

  • Bone Healing Sequence

    1. Inflammation and hematoma formation
    2. Phagocytosis of debris
    3. Fibroblast and chondroblast activity (soft callus)
    4. Osteoblasts form new bone
    5. Remodeling and strengthening

  • Compartment Syndrome

    Increased pressure within a muscle compartment impairs blood flow and nerve function, causing severe pain, numbness, weakness, and possible limb ischemia.

  • Difference Between Sprain and Strain

    Sprain: Injury to a ligament.
    Strain: Injury to a tendon or muscle.

  • RICE Method for Soft Tissue Injuries

    Rest, Ice, Compression, and Elevation to reduce swelling and promote healing.

  • Osteoporosis

    Condition of low bone density that increases fracture risk.

  • Parkinson Disease Key Feature

    Dopamine deficiency causing resting tremor and shuffling gait.

  • Multiple Sclerosis (MS)

    Demyelination disorder causing variable motor, sensory, and vision problems.

  • Guillain-Barre Syndrome

    Ascending weakness following infection or vaccination, with risk of respiratory failure.

  • Cerebrovascular Stroke Types

    Ischemic stroke: Blood flow blockage causing tissue death.
    Hemorrhagic stroke: Vessel rupture causing bleeding and increased ICP.

  • Brain Death Criteria

    Irreversible loss of all brain and brainstem function; no reflexes or spontaneous breathing.

  • Aphasia Types

    Receptive (Wernicke): Cannot understand language.
    Expressive (Broca): Cannot express language.
    Global: Both comprehension and expression impaired.