In glycolysis (from one molecule of glucose to two molecules of pyruvate), what is the net gain of ATP per glucose molecule?
A
2 ATP
B
1 ATP
C
0 ATP
D
4 ATP
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1
Understand the overall process of glycolysis: one molecule of glucose (6 carbons) is converted into two molecules of pyruvate (3 carbons each).
Identify the ATP-consuming steps: In the energy investment phase, 2 ATP molecules are used to phosphorylate glucose and its intermediates.
Identify the ATP-producing steps: In the energy payoff phase, 4 ATP molecules are produced by substrate-level phosphorylation (2 ATP per each of the two 3-carbon molecules).
Calculate the net ATP gain by subtracting the ATP used from the ATP produced: Net ATP = ATP produced - ATP consumed.
Conclude that the net gain of ATP per glucose molecule in glycolysis is the difference found in the previous step.