In the glycolysis pathway, what is the net amount of ATP produced per molecule of glucose converted to two molecules of pyruvate?
A
36 ATP (net)
B
0 ATP (net)
C
2 ATP (net)
D
4 ATP (net)
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1
Understand that glycolysis is the metabolic pathway that converts one molecule of glucose into two molecules of pyruvate, producing energy in the form of ATP and NADH.
Identify the ATP-consuming steps: In the initial phase of glycolysis (investment phase), 2 ATP molecules are used to phosphorylate glucose and its intermediates.
Identify the ATP-producing steps: In the later phase (payoff phase), 4 ATP molecules are generated through substrate-level phosphorylation as the pathway converts intermediates into pyruvate.
Calculate the net ATP production by subtracting the ATP consumed from the ATP produced: Net ATP = ATP produced - ATP consumed.
Conclude that the net ATP yield per glucose molecule in glycolysis is 2 ATP, since 4 ATP are produced and 2 ATP are used.