객관식
Which of the following statements about irreversible inhibitors is correct?
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7. Enzyme Inhibition and Regulation
Irreversible Inhibition
객관식
A suicide inhibitor of an enzyme is one that:
A
Is reversible.
B
Is activated by one type of enzyme for the purpose of inhibiting a second type of enzyme.
C
Is competitive with the enzyme and inactivates the substrate.
D
Is competitive with the substrate and inactivates the enzyme.
검증된 단계별 안내1
Understand the concept of a suicide inhibitor: A suicide inhibitor, also known as a mechanism-based inhibitor, is a type of irreversible enzyme inhibitor that binds to the enzyme as a substrate and is initially processed by the normal catalytic mechanism.
Recognize the irreversible nature: Unlike reversible inhibitors, suicide inhibitors form a covalent bond with the enzyme, leading to permanent inactivation.
Identify the competitive aspect: Suicide inhibitors often compete with the natural substrate for the active site of the enzyme, but once bound, they undergo a transformation that inactivates the enzyme.
Clarify the inactivation process: The inhibitor is converted into a reactive form by the enzyme itself, which then covalently modifies and inactivates the enzyme, preventing further catalytic activity.
Differentiate from other inhibitors: Unlike reversible inhibitors that can dissociate from the enzyme, suicide inhibitors permanently inactivate the enzyme, making them distinct from competitive inhibitors that do not alter the enzyme's structure permanently.
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