Why is the hydrophobic nature of lipid hormones significant for their function?

A researcher is studying a lipid hormone that can bind to both intracellular and extracellular receptors. What implications does this have for signal transduction and cellular responses?

What is a unique aspect of lipid hormone signaling compared to GPCRs and RTKs?

How might a lipid hormone that binds to both intracellular and extracellular receptors influence cellular responses differently?

What would be the consequence of a genetic mutation that prevents cholesterol synthesis on steroid hormone function?

How might lipid hormones influence metabolic responses when they bind to intracellular receptors?

In a physiological context where a lipid hormone is deficient, what potential impact might this have on cellular processes?