in-a-scenario-where-the-gdp-to-gtp-exchange-in-the-stimulatory-g-protein-is-inhi

Question

In a scenario where the GDP to GTP exchange in the stimulatory G protein is inhibited, what would be the immediate consequence in the signaling pathway?

Accepted Answer

The alpha subunit would remain inactive and unable to dissociate from the beta gamma subunits.

Answer

The GPCR would undergo a conformational change without ligand binding.

Answer

Protein kinase A would be activated without the need for cyclic AMP.

Answer

Adenylate cyclase would be activated directly by the beta gamma subunits.