Which component of the electron transport chain is primarily responsible for transferring electrons from NADH to ubiquinone (coenzyme Q)?
A
Complex I (NADH:ubiquinone oxidoreductase)
B
Complex II (succinate dehydrogenase)
C
Complex IV (cytochrome c oxidase)
D
Complex III (cytochrome bc_1 complex)
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1
Understand the role of the electron transport chain (ETC): The ETC is a series of protein complexes and molecules embedded in the inner mitochondrial membrane that transfer electrons from electron carriers (like NADH and FADH2) to oxygen, generating a proton gradient used for ATP synthesis.
Identify the electron carrier involved: NADH is the molecule donating electrons in this case. It is oxidized to NAD⁺, releasing high-energy electrons into the ETC.
Determine the first complex in the ETC: Complex I, also known as NADH:ubiquinone oxidoreductase, is responsible for accepting electrons from NADH. It transfers these electrons to ubiquinone (coenzyme Q), which is a mobile electron carrier in the membrane.
Understand the mechanism of Complex I: Complex I uses the energy from electron transfer to pump protons (H⁺) across the inner mitochondrial membrane, contributing to the proton gradient necessary for ATP synthesis.
Eliminate other options: Complex II (succinate dehydrogenase) transfers electrons from FADH2, not NADH. Complex III (cytochrome bc₁ complex) and Complex IV (cytochrome c oxidase) are downstream in the ETC and do not directly interact with NADH.