Understand that the human genome is the complete set of DNA, including all of its genes.
Recognize that each human cell contains 23 pairs of chromosomes, totaling 46 chromosomes.
Recall that genes are segments of DNA that contain the instructions for building proteins, which perform most life functions.
Consider that the human genome contains tens of thousands of genes, which are distributed across the 23 pairs of chromosomes.
Conclude that the number of genes in the human genome is best described as 'tens of thousands,' which is a more accurate representation than the other options provided.