Understand that autosomes are chromosomes that are not involved in determining the sex of an individual. Humans have a total of 46 chromosomes.
Out of these 46 chromosomes, 2 are sex chromosomes (X and Y), which determine the sex of the individual.
Subtract the 2 sex chromosomes from the total number of chromosomes: 46 - 2 = 44.
The remaining 44 chromosomes are autosomes. Since chromosomes come in pairs, divide the number of autosomes by 2 to find the number of pairs: 44 / 2 = 22.