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General Biology: Viruses

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  • What is a virus?

    A virus is an infectious particle consisting of genes packaged in a protein coat. It cannot reproduce or carry out metabolism outside a host cell.
  • What are the main components of a virus?

    A virus consists of nucleic acid (DNA or RNA) enclosed in a protein coat called a capsid. Some viruses also have a membranous envelope.
  • How are viruses classified based on their genome?

    Viruses are classified as DNA or RNA viruses, with genomes that can be single- or double-stranded, linear or circular.
  • What is a capsid and what is it made of?

    A capsid is the protein shell enclosing the viral genome, built from protein subunits called capsomeres.
  • What is the function of viral envelopes?

    Viral envelopes, derived from host membranes, surround some viruses and contain viral and host molecules that help the virus infect host cells.
  • What is a bacteriophage?

    A bacteriophage (phage) is a virus that infects bacteria, characterized by an elongated capsid head and a protein tail used to inject DNA into the host.
  • What does it mean that viruses are obligate intracellular parasites?

    Viruses can replicate only inside host cells, using the host's machinery to produce viral components.
  • What is the lytic cycle in phages?

    The lytic cycle is a viral replicative cycle that produces new phages and lyses the host cell, killing it.
  • What is the lysogenic cycle in phages?

    The lysogenic cycle integrates viral DNA into the host chromosome as a prophage, replicating without killing the host until triggered to enter the lytic cycle.
  • How do bacteria defend against phages?

    Bacteria use surface protein mutations, restriction enzymes to cut foreign DNA, and the CRISPR-Cas system to target and destroy phage DNA.
  • What is the CRISPR-Cas system?

    A bacterial adaptive immune system that stores phage DNA sequences and uses Cas proteins to recognize and cut invading phage DNA.
  • How do animal viruses differ from bacteriophages?

    Animal viruses often have RNA genomes and membranous envelopes, unlike most bacteriophages.
  • What is a retrovirus?

    A retrovirus is an RNA virus that uses reverse transcriptase to copy its RNA genome into DNA, which integrates into the host genome as a provirus.
  • What is a provirus?

    A provirus is viral DNA integrated permanently into the host genome, transcribed into RNA for viral protein synthesis and new virus genomes.
  • How do viruses evolve?

    Viruses likely evolved from mobile genetic elements like plasmids and transposons and continue to evolve rapidly through mutation and recombination.
  • How do viruses cause disease in animals?

    Viruses damage cells by lysing them, releasing enzymes, producing toxins, or having toxic molecular components.
  • What is a vaccine?

    A vaccine is a harmless derivative of a pathogen that stimulates the immune system to defend against the harmful pathogen.
  • What causes emerging viral diseases?

    Emerging viruses arise from mutation, spread from isolated populations, or transmission from animals to humans.
  • How do influenza viruses cause epidemics and pandemics?

    Influenza viruses mutate rapidly and reassort their segmented RNA genomes, creating new strains that can cause widespread outbreaks.
  • How do plant viruses spread?

    Plant viruses spread by horizontal transmission through damaged cell walls and vertical transmission from parent to offspring.
  • What are prions?

    Prions are infectious misfolded proteins that cause degenerative brain diseases by converting normal proteins into the misfolded form.