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Mendelian Genetics and Patterns of Inheritance

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  • What is heredity?

    Heredity is the transmission of traits from one generation to the next.

  • Who is Gregor Mendel and what did he discover?

    Gregor Mendel discovered that parents pass on discrete genes responsible for inherited traits, which retain their identity across generations.

  • Why did Mendel choose garden peas for his experiments?

    Garden peas were easy to grow and had distinct, easily distinguishable varieties for traits.

  • Define character and trait in genetics.

    A character is a heritable feature that varies among individuals, while a trait is a variant of a character, such as flower color being a character and purple or white being traits.

  • What is a purebred variety in Mendel's experiments?

    A purebred variety is a plant that, when self-fertilized, produces offspring identical to itself for a specific trait.

  • What is a hybrid in genetics?

    A hybrid is the offspring of two different purebred varieties.

  • What are the P, F1, and F2 generations in Mendel's crosses?

    P generation are the purebred parents, F1 generation are their hybrid offspring, and F2 generation are the offspring from crossing F1 individuals.

  • State Mendel's Law of Segregation.

    Each organism inherits two alleles for a gene, which segregate during gamete formation so each gamete carries only one allele.

  • What is the difference between homozygous and heterozygous genotypes?

    Homozygous means having two identical alleles for a gene; heterozygous means having two different alleles.

  • Define dominant and recessive alleles.

    A dominant allele determines the organism's appearance when present, while a recessive allele has no noticeable effect in heterozygotes.

  • What is a Punnett square used for?

    A Punnett square predicts the possible allele combinations and genotypes of offspring from a genetic cross.

  • What is the phenotypic ratio in Mendel's monohybrid F2 generation for flower color?

    The phenotypic ratio is 3 purple : 1 white flower color in the F2 generation.

  • Explain Mendel's Law of Independent Assortment.

    Alleles of different genes assort independently during gamete formation, so inheritance of one trait does not affect another.

  • What is a dihybrid cross?

    A cross between two organisms heterozygous for two characters, used to study independent assortment.

  • What is a testcross and its purpose?

    A testcross is a mating between an individual with a dominant phenotype but unknown genotype and a homozygous recessive individual to determine the unknown genotype.

  • How do geneticists use pedigrees?

    Pedigrees are family trees used to analyze inheritance patterns of traits in humans.

  • What does dominance mean in genetics?

    Dominance means a heterozygous genotype results in the dominant phenotype, not that the trait is more common or normal.

  • Give examples of human traits controlled by a single gene.

    Examples include freckles, widow's peak hairline, and some genetic disorders like cystic fibrosis and achondroplasia.

  • What is incomplete dominance?

    Incomplete dominance occurs when heterozygotes have an intermediate phenotype between the two homozygotes.

  • Explain codominance with the ABO blood group example.

    In codominance, both alleles are expressed equally, as in IAIB genotype producing type AB blood with both A and B carbohydrates.

  • What is pleiotropy?

    Pleiotropy occurs when one gene influences multiple phenotypic traits, such as sickle-cell disease affecting red blood cells and causing multiple symptoms.

  • Define polygenic inheritance.

    Polygenic inheritance is when multiple genes additively affect a single phenotypic character, like human height.

  • What is epigenetic inheritance?

    Transmission of traits through chemical modifications of DNA or chromosomal proteins that do not change the DNA sequence but can be inherited.

  • What is the chromosome theory of inheritance?

    Genes are located at specific loci on chromosomes, and chromosome behavior during meiosis explains inheritance patterns.

  • What are linked genes?

    Linked genes are genes located close together on the same chromosome and tend to be inherited together, not assorting independently.

  • How is sex determined in humans?

    Humans have sex chromosomes X and Y; XX individuals are female, XY individuals are male.

  • What are sex-linked genes?

    Genes located on sex chromosomes, mostly on the X chromosome, often showing unique inheritance patterns like red-green colorblindness.

  • How is red-green colorblindness inherited?

    It is a sex-linked recessive trait mostly affecting males, who have only one X chromosome.

  • What is the significance of carriers in recessive genetic disorders?

    Carriers have one recessive allele but do not show symptoms; they can pass the disorder to offspring if both parents are carriers.