Understand that DNA replication is the process by which a cell makes an exact copy of its DNA, which is essential before cell division.
Recall that in eukaryotic cells, DNA is located inside the nucleus, and replication must occur where the DNA is housed.
Identify the phase of the cell cycle when DNA replication occurs, which is the S phase (Synthesis phase) of interphase.
Recognize that lysosomes are involved in macromolecule degradation, not DNA replication, so they are not the site of replication.
Note that the Golgi apparatus processes proteins and the cytoplasm contains ribosomes for protein synthesis, but neither is the site of DNA replication.