교과서 질문
Explain the apparent paradox that both hypermethylation and hypomethylation of DNA are often found in the same cancer cell.
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19. Cancer Genetics
Overview of Cancer
객관식
How does cancer differ from most other genetic disorders?
A
Cancer is always inherited from parents, while most other genetic disorders are acquired during a person's lifetime.
B
Cancer is caused by viral infections, whereas most other genetic disorders are caused by environmental factors.
C
Cancer is typically caused by the accumulation of multiple somatic mutations over time, whereas most other genetic disorders are caused by inherited germline mutations.
D
Cancer only affects the reproductive cells, while most other genetic disorders affect somatic cells.
검증된 단계별 안내1
Understand the difference between somatic mutations and germline mutations: Somatic mutations occur in non-reproductive cells and are acquired during a person's lifetime, while germline mutations are inherited from parents and present in reproductive cells.
Recognize that cancer is generally caused by the accumulation of multiple somatic mutations in a single cell lineage, which leads to uncontrolled cell growth and tumor formation.
Contrast this with most other genetic disorders, which are typically caused by inherited germline mutations that are present in every cell of the body from birth.
Note that cancer is not usually inherited directly but results from mutations acquired over time, whereas many genetic disorders are passed down through families via germline mutations.
Summarize that the key difference lies in the origin of the mutations: cancer arises from somatic mutations accumulated during life, while most genetic disorders stem from inherited germline mutations.
