Which type of mutation occurs only in reproductive cells (gametes) and can therefore be passed to offspring?
A
Frameshift mutation
B
Silent (synonymous) mutation
C
Somatic mutation
D
Germ-line mutation
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1
Understand the difference between mutations occurring in somatic cells and those in germ-line cells. Somatic mutations happen in body cells and are not passed to offspring, while germ-line mutations occur in reproductive cells (gametes) and can be inherited.
Review the definitions of the mutation types listed: Frameshift mutations involve insertions or deletions that shift the reading frame; silent mutations change the DNA sequence without altering the amino acid; somatic mutations occur in non-reproductive cells.
Recognize that only mutations in germ-line cells can be transmitted to the next generation because these cells give rise to gametes (sperm and eggs).
Identify that the term 'germ-line mutation' specifically refers to mutations in reproductive cells that can be passed to offspring, distinguishing it from somatic mutations.
Conclude that the correct answer is 'germ-line mutation' because it uniquely describes mutations in gametes that are heritable.