A short RNA molecule was isolated that demonstrated a hyperchromic shift, indicating secondary structure. Its sequence was determined to be
5'-AGGCGCCGACUCUACU-3'
If the molecule were a tRNA fragment containing a CGA anticodon, what would the corresponding codon be?

검증된 단계별 안내

Identify the anticodon sequence given in the problem, which is CGA. Remember that anticodons are written in the 3' to 5' direction to pair with codons in the 5' to 3' direction on mRNA.

Reverse the anticodon sequence to get its 5' to 3' orientation. For the anticodon CGA (3' to 5'), the 5' to 3' sequence would be AGC.

Determine the complementary codon sequence by pairing each base of the anticodon with its complementary base according to base pairing rules: C pairs with G, G pairs with C, and A pairs with U (since this is RNA).

Write the codon sequence in the 5' to 3' direction, which will be complementary and antiparallel to the anticodon. This means the codon will be 5'-GCU-3'.

Confirm that the codon sequence corresponds to the anticodon and is consistent with RNA base pairing rules, ensuring the codon can be correctly recognized by the tRNA fragment with the CGA anticodon.

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주요 개념

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Codon-Anticodon Base Pairing

Codons are three-nucleotide sequences on mRNA that specify amino acids, while anticodons are complementary three-nucleotide sequences on tRNA. Base pairing between codon and anticodon follows Watson-Crick rules (A pairs with U, C pairs with G) and is essential for accurate translation of genetic information into proteins.

tRNA Structure and Function

tRNA molecules have a characteristic cloverleaf secondary structure and carry specific anticodons that recognize codons on mRNA. The anticodon loop binds to the mRNA codon during translation, ensuring the correct amino acid is incorporated into the growing polypeptide chain.

Hyperchromic Shift and RNA Secondary Structure

A hyperchromic shift refers to an increase in UV absorbance due to the disruption of base stacking in nucleic acids, indicating the presence of secondary structures like hairpins or loops. This property helps identify folded RNA regions, such as those found in tRNA fragments.

A short RNA molecule was isolated that demonstrated a hyperchromic shift, indicating secondary structure. Its sequence was determined to be5'-AGGCGCCGACUCUACU-3'If the molecule were a tRNA fragment containing a CGA anticodon, what would the corresponding codon be?