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Ch. 20 - Quantitative Genetics and Multifactorial Traits
Klug - Essentials of Genetics 10th Edition
Klug10th EditionEssentials of GeneticsISBN: 9780135588789당신이 사용하는 게 아니라요?교과서 변경
20장, 문제 14

The mean and variance of plant height of two highly inbred strains (P₁ and P₂) and their progeny (F₁ and F₂) are shown here.


  Strain  Mean (cm)  Variance 
   P₁     34.2        4.2
   P₂     55.3        3.8
   F₁     44.2        5.6
   F₂     46.3       10.3


Calculate the broad-sense heritability (H²) of plant height in this species.

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1
Identify the components needed to calculate broad-sense heritability (H²). Broad-sense heritability is defined as the proportion of total phenotypic variance that is due to genetic variance. Mathematically, it is expressed as \(H^{2} = \frac{V_{G}}{V_{P}}\), where \(V_{G}\) is the genetic variance and \(V_{P}\) is the total phenotypic variance.
Estimate the environmental variance (\(V_{E}\)) using the variance of the parental strains (P₁ and P₂). Since these strains are highly inbred and genetically uniform, their variance mainly reflects environmental variance. Calculate \(V_{E}\) as the average of the variances of P₁ and P₂: \(V_{E} = \frac{4.2 + 3.8}{2}\).
Determine the total phenotypic variance (\(V_{P}\)) in the F₂ generation, which is given as 10.3. This variance includes both genetic and environmental components.
Calculate the genetic variance (\(V_{G}\)) in the F₂ generation by subtracting the environmental variance from the total phenotypic variance: \(V_{G} = V_{P} - V_{E}\).
Finally, compute the broad-sense heritability using the formula \(H^{2} = \frac{V_{G}}{V_{P}}\) by substituting the values of \(V_{G}\) and \(V_{P}\) obtained in the previous steps.

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Broad-Sense Heritability (H²)

Broad-sense heritability (H²) measures the proportion of total phenotypic variance in a trait that is due to genetic variance. It is calculated as the ratio of genetic variance to total phenotypic variance, indicating how much of the observed variation is inherited. H² helps predict the response to selection in breeding programs.
추천 영상:
가이드 코스
07:04
Calculating Heritability

Phenotypic Variance and Genetic Variance

Phenotypic variance (Vp) is the total variation observed in a trait, arising from both genetic and environmental factors. Genetic variance (Vg) is the portion of phenotypic variance attributable to genetic differences among individuals. In inbred strains, environmental variance can be estimated from within-strain variance, aiding in separating genetic effects.
추천 영상:
가이드 코스
08:34
Analyzing Trait Variance

Use of Inbred Strains and Progeny Variance in Heritability Estimation

Highly inbred parental strains have minimal genetic variation within themselves, so their variance mainly reflects environmental effects. The increased variance in F₂ progeny compared to parents reflects genetic segregation and recombination. Comparing variances of parents and progeny allows estimation of genetic variance and thus broad-sense heritability.
추천 영상:
가이드 코스
07:04
Calculating Heritability
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Calculate broad-sense (H²) and narrow-sense (h²) heritabilities for each trait in this herd.

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A hypothetical study investigated the vitamin A content and the cholesterol content of eggs from a large population of chickens. The following variances (V) were calculated.

Which trait, if either, is likely to respond to selection?

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In a herd of dairy cows the narrow-sense heritability for milk protein content is 0.76, and for milk butterfat it is 0.82. The correlation coefficient between milk protein content and butterfat is 0.91. If the farmer selects for cows producing more butterfat in their milk, what will be the most likely effect on milk protein content in the next generation?

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The following variances were calculated for two traits in a herd of hogs.

Which of the two traits will respond best to selection by a breeder? Why?

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Corn plants from a test plot are measured, and the distribution of heights at 10-cm intervals is recorded in the following table: 

 Height (cm)   Plants (no.)    

100          20    

110          60    

120          90    

130         130    

140         180   

 150         120    

160          70    

170         50    

180         40 

Calculate 

(a) the mean height, 

(b) the variance, 

(c) the standard deviation, and 

(d) the standard error of the mean. 

Plot a rough graph of plant height against frequency. Do the values represent a normal distribution? Based on your calculations, how would you assess the variation within this population?

941
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A hypothetical study investigated the vitamin A content and the cholesterol content of eggs from a large population of chickens. The following variances (V) were calculated.

Calculate the narrow-sense heritability (h²) for both traits.

475
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