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How do drugs that inhibit nucleic acid synthesis (e.g., rifampicin & quinolones) differ from inhibitors of protein synthesis (e.g., tetracyclines & aminoglycosides)?
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- 1. Introduction to Microbiology3h 27m
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28. Antimicrobial Drugs
Inhibitors of Nucleic Acid Synthesis
Multiple Choice
Which of the following correctly matches the drug with its target?
A
Rifamycin → Topoisomerase.
B
Rifamycin → RNA polymerase.
C
Quinolones → 50s subunit.
D
Quinolones → Primase.
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검증된 단계별 안내1
Step 1: Understand the mechanism of action of Rifamycin. Rifamycin is an antibiotic that specifically targets bacterial RNA polymerase, inhibiting RNA synthesis and thus blocking transcription.
Step 2: Review the target of Quinolones. Quinolones are known to inhibit bacterial DNA gyrase and topoisomerase IV, enzymes involved in DNA replication, not ribosomal subunits or primase.
Step 3: Recall the targets of antibiotics that affect the ribosome. For example, drugs like macrolides target the 50S ribosomal subunit, but Quinolones do not.
Step 4: Match each drug to its correct target based on their known mechanisms: Rifamycin → RNA polymerase; Quinolones → DNA gyrase/topoisomerase; Macrolides → 50S ribosomal subunit.
Step 5: Conclude that the correct pairing is Rifamycin with RNA polymerase, and Quinolones do not target the 50S subunit or primase.
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