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Adaptive Immunity and Host Responses in Microbiology

컨트롤 버튼이 '내비게이션' 모드로 변경되었습니다.
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  • Primary lymphoid organs

    Red bone marrow and thymus where lymphocytes mature.

  • Secondary lymphoid organs

    Include lymph nodes, spleen, tonsils, and MALT where immune responses are initiated.

  • Antigen (epitope)

    A specific part of an antigen recognized by immune cells; can be exogenous, endogenous, or autoantigens.

  • MHC class I molecules

    Present on all nucleated cells and display endogenous antigens to cytotoxic T cells.

  • MHC class II molecules

    Found on antigen-presenting cells and present exogenous antigens to helper T cells.

  • Cytotoxic T cells

    Destroy infected or abnormal cells by recognizing antigen presented with MHC I.

  • Helper T cells

    Coordinate immune responses by activating other immune cells, recognizing antigen with MHC II.

  • Regulatory T cells

    Suppress immune responses to maintain self-tolerance and prevent autoimmunity.

  • Clonal deletion of T cells

    Process where T cells that do not recognize MHC or recognize self-antigens undergo apoptosis to prevent autoimmunity.

  • B cell receptor (BCR) structure

    Composed of heavy and light chains with variable and constant regions and antigen-binding sites.

  • Functions of antibodies

    Include complement activation, neutralization, opsonization, agglutination, and ADCC.

  • IgM antibody

    The first antibody produced during an immune response.

  • IgG antibody

    The most common and longest-lasting antibody in circulation.

  • IgA antibody

    Found mainly in body secretions like saliva and mucus, protecting mucosal surfaces.

  • IgE antibody

    Involved in allergic reactions and defense against parasitic infections.

  • IgD antibody

    Function is not well understood but is found on B cell surfaces.

  • Clonal deletion of B cells

    Occurs in bone marrow; self-reactive B cells may be deleted, inactivated, or change their BCR to prevent autoimmunity.

  • Interleukins (ILs)

    Cytokines that facilitate communication and signaling among leukocytes.

  • Interferons (IFNs)

    Proteins with antiviral activity that also act as cytokines to modulate immune responses.

  • Tumor necrosis factor (TNF)

    Secreted by macrophages and T cells to kill tumor cells and regulate inflammation.

  • Chemokines

    Cytokines that direct leukocyte movement toward sites of infection or injury.

  • Steps of cell-mediated immune response

    Include antigen presentation, helper T cell differentiation, clonal expansion, and self-stimulation.

  • Perforin-granzyme pathway

    Mechanism used by cytotoxic T cells to induce apoptosis in infected cells.

  • Antibody immune response steps

    Involve antigen presentation, helper T cell activation, B cell activation, and B cell proliferation and differentiation.

  • Plasma cells

    Activated B cells that produce and secrete large amounts of antibodies.

  • Memory B cells

    Long-lived B cells that provide faster and stronger response upon re-exposure to antigen.

  • Natural acquired immunity

    Immunity gained through natural exposure to pathogens, either active (infection) or passive (maternal antibodies).

  • Artificially acquired immunity

    Immunity gained through medical intervention, such as vaccines (active) or antibody therapy (passive).