Negri bodies are associated with which of the following?

a. Marburg virus
b. Hantavirus
c. Coltivirus
d. Rabies virus

검증된 단계별 안내

Step 1: Understand what Negri bodies are. Negri bodies are cytoplasmic inclusion bodies found in certain infected cells, specifically neurons, and are considered pathognomonic for a particular viral infection.

Step 2: Recall the viruses listed in the options and their characteristics: Marburg virus causes hemorrhagic fever, Hantavirus is associated with pulmonary syndrome, Coltivirus causes Colorado tick fever, and Rabies virus causes rabies with neurological symptoms.

Step 3: Identify which virus is known to produce Negri bodies. Negri bodies are characteristic of the Rabies virus infection and are used as a diagnostic marker in brain tissue samples.

Step 4: Confirm that Negri bodies are not associated with Marburg virus, Hantavirus, or Coltivirus, as these viruses do not produce such inclusion bodies.

Step 5: Conclude that the correct association of Negri bodies is with the Rabies virus.

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주요 개념

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Negri Bodies

Negri bodies are distinctive cytoplasmic inclusion bodies found in nerve cells infected by the rabies virus. They serve as a diagnostic hallmark in histopathology for rabies infection, appearing as eosinophilic, round or oval structures within neurons.

Rabies Virus

Rabies virus is a neurotropic virus from the Lyssavirus genus that causes fatal encephalitis in mammals. It travels through peripheral nerves to the central nervous system, where it induces characteristic pathological changes including the formation of Negri bodies.

Viral Inclusion Bodies

Viral inclusion bodies are aggregates of viral particles or altered host cell components visible under a microscope during infection. They help identify specific viral infections, as different viruses produce unique inclusion bodies in infected cells.

Negri bodies are associated with which of the following?a. Marburg virusb. Hantavirusc. Coltivirusd. Rabies virus