Which of the following shows a correct chronological order of events in inflammation?
a. Neutrophil recruitment, macrophage recruitment, vascular changes, resolution
b. Vascular changes, resolution, neutrophil recruitment, macrophage recruitment
c. Vascular changes, macrophage recruitment, neutrophil recruitment, resolution
d. Vascular changes, macrophage recruitment, resolution, neutrophil recruitment
e. Vascular changes, neutrophil recruitment, macrophage recruitment, resolution

검증된 단계별 안내

Step 1: Understand the process of inflammation, which typically begins with vascular changes such as vasodilation and increased vascular permeability to allow immune cells to access the affected tissue.

Step 2: Recognize that neutrophils are usually the first immune cells recruited to the site of inflammation, arriving quickly to phagocytose pathogens and debris.

Step 3: After neutrophils, macrophages are recruited to the site; they help in clearing dead cells and orchestrating tissue repair.

Step 4: Following the immune cell recruitment and activity, the inflammation process moves towards resolution, where tissue repair and the return to homeostasis occur.

Step 5: Based on this sequence, the correct chronological order is: vascular changes, neutrophil recruitment, macrophage recruitment, and resolution.

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주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Vascular Changes in Inflammation

Vascular changes are the initial events in inflammation, involving vasodilation and increased permeability of blood vessels. These changes allow immune cells and plasma proteins to exit the bloodstream and enter the affected tissue, setting the stage for the immune response.

Neutrophil and Macrophage Recruitment

Neutrophils are the first immune cells recruited to the site of inflammation, arriving quickly to phagocytose pathogens. Macrophages arrive later to clear debris, dead cells, and orchestrate tissue repair, marking a transition from acute to resolution phases.

Resolution of Inflammation

Resolution is the final phase where inflammation subsides, damaged tissue is repaired, and homeostasis is restored. This phase involves the clearance of immune cells and the release of anti-inflammatory mediators to prevent chronic inflammation.