Skip to main content
Ch. 18 - Nervous System Infections
Norman-McKay- Microbiology: Basic and Clinical Principles 2nd Edition
Norman-McKay2nd EditionMicrobiology: Basic and Clinical PrinciplesISBN: 9780137661619당신이 사용하는 게 아니라요?교과서 변경
14장, 문제 3

A patient’s lab data report has come back with a positive ELISA for pneumococcal C polysaccharide from CSF samples. The MOST appropriate next step for a health professional to recommend is to
a. culture from the CSF sample to test for antibiotic resistance.
b. administer tetracycline.
c. administer cephalosporin.
d. wait for RT-PCR confirmation before antibiotic treatment.

검증된 단계별 안내
1
Step 1: Understand the significance of a positive ELISA for pneumococcal C polysaccharide in cerebrospinal fluid (CSF). This indicates the presence of Streptococcus pneumoniae, a common cause of bacterial meningitis.
Step 2: Recognize that bacterial meningitis is a medical emergency requiring prompt antibiotic treatment to reduce morbidity and mortality.
Step 3: Know that culture from the CSF is important for identifying the bacteria and testing antibiotic susceptibility, but treatment should not be delayed while waiting for culture results.
Step 4: Identify the appropriate antibiotic class for empiric treatment of pneumococcal meningitis. Cephalosporins (such as ceftriaxone or cefotaxime) are commonly recommended first-line agents due to their effectiveness and ability to penetrate the blood-brain barrier.
Step 5: Conclude that the best immediate action is to start empiric antibiotic therapy with a cephalosporin rather than waiting for further confirmation or using antibiotics like tetracycline, which are not first-line for this infection.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.
영상 길이:
1m
도움이 되었나요?

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

ELISA for Pneumococcal C Polysaccharide

ELISA (Enzyme-Linked Immunosorbent Assay) detects specific bacterial antigens, such as pneumococcal C polysaccharide, in clinical samples like CSF. A positive result indicates the presence of Streptococcus pneumoniae, a common cause of bacterial meningitis, requiring prompt clinical action.
추천 영상:
03:08
Formation & Breakdown of Polysaccharides

Empiric Antibiotic Therapy in Bacterial Meningitis

Bacterial meningitis is a medical emergency needing immediate empiric antibiotic treatment to reduce morbidity and mortality. Cephalosporins are often first-line antibiotics due to their effectiveness against common pathogens like S. pneumoniae and good CNS penetration.
추천 영상:
03:49
Mechanism of Natural Transformation

Role of Culture and Molecular Confirmation in Diagnosis

While culture and molecular tests like RT-PCR confirm diagnosis and guide antibiotic resistance profiling, waiting for these results before starting treatment can delay critical care. Initial management prioritizes rapid empiric therapy based on clinical and preliminary lab findings.
추천 영상:
01:32
Intro to Molecular Koch's Postulates
관련 실천
교과서 질문

During a lumbar puncture procedure, the nurse observed that the patient’s CSF pressure was high. However, when the analysis of the CSF sample comes back, the glucose levels are normal. The nurse would most likely suspect:

a. arboviral meningitis.

b. Neisseria meningitidis.

c. Listeria monocytogenes.

d. poliovirus.

1178
views
교과서 질문

A patient under one year old is vomiting, drowsy, floppy (flaccid), and unresponsive. Both infant botulism and infant meningitis caused by other bacteria are suspected. Which piece of information would best help narrow down the possible diagnosis?

a. The child has spent almost no time outside the home.

b. The child is being breast-fed.

c. The child was born one month ago.

d. The child has a very high fever.

1092
views
교과서 질문

CSF glucose levels are often assessed to differentiate between bacterial and viral meningitis. This is because

a. bacteria cells use glucose and lower the overall concentration in the CSF.

b. viral meningitis causes inflammation that blocks glucose transport into the CSF.

c. viral infection of the meninges causes cell lysis, releasing glucose into the CSF.

d. None of the above.

1185
views
교과서 질문

Viral meningitis is more common than other forms of meningitis because

a. these infectious agents are all intracellular, evading the immune system.

b. there are more types of viruses than bacteria because they evolve more quickly.

c. the small size of viruses makes them able to pass more easily through the blood–brain barrier.

d. viruses are spread person to person more easily than bacteria, fungi, or protozoans.

1318
views
교과서 질문

A patient is admitted who is complaining of headache, disorientation, and numbness in his left arm. He was bitten by a raccoon two days before. The FIRST step taken to help this patient would be

a. retrieving and testing the raccoon’s brain tissues for the rabies virus.

b. collecting a CSF sample from the patient.

c. performing a tissue biopsy on the patient to look for Negri bodies.

d. administering an anti-rabies vaccine as well as anti-rabies antibodies.

1141
views